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Association Between Occult Kidney Disease and COVID-19 Mortality: Evidence from a Retrospective Study
Fernando Guerrero-Romero1, Gerardo Martínez-Aguilar1, Mayela Ríos-Mier1
1Unidad de Investigación Biomédica, Delegación Durango, Instituto Mexicano del Seguro Social, Durango, México.
Iranian Journal of Kidney Diseases
|June 3, 2026
Summary
Occult kidney disease (OKD) is linked to higher mortality in COVID-19 patients. Early detection of this early-stage renal failure is crucial for managing COVID-19 outcomes.
Area of Science:
- Nephrology
- Infectious Diseases
- Critical Care Medicine
Background:
- Occult kidney disease (OKD), an early stage of renal failure, is often undetected in routine screenings.
- COVID-19 has been associated with various complications, including kidney injury.
Purpose of the Study:
- To investigate the association between occult kidney disease (OKD) and disease severity and mortality in COVID-19 patients.
Main Methods:
- A retrospective study included 809 COVID-19 patients confirmed by RT-PCR.
- OKD was defined by an estimated glomerular filtration rate < 60 ml/min/1.73 m2 and creatinine ≤1.3 mg/dl.
Main Results:
- The prevalence of OKD, acute kidney injury, and chronic kidney disease was 7.7%, 15.0%, and 12.4%, respectively.
- Adjusted logistic regression revealed OKD (OR=1.86), acute kidney injury (OR=2.03), and chronic kidney disease (OR=3.07) were significantly associated with COVID-19 mortality.
Conclusions:
- Occult kidney disease is an independent risk factor for increased mortality in patients with COVID-19.
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