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Related Concept Videos

Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

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Longitudinal Intravital Imaging of Brain Tumor Cell Behavior in Response to an Invasive Surgical Biopsy
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Artificial intelligence based techniques for brain tumor analysis: A systematic review.

Oluwabukola G Adegboro1, Julia Dietlmeier2, Noel E O'Connor2

  • 1Dublin City University, Dublin, Ireland; Research Ireland Centre for Research Training in Machine Learning (ML-Labs), Dublin, Ireland.

Artificial Intelligence in Medicine
|June 3, 2026
PubMed
Summary

This review examines how computer programs identify brain tumors. While many studies use advanced algorithms to find and categorize these growths, none are currently used in hospitals. The authors highlight a need for more transparent, explainable technology and better methods for analyzing complex medical images.

Keywords:
Artificial intelligenceBrain tumorClassificationExplainable AI (XAI)Magnetic Resonance Imaging (MRI)SegmentationSystematic reviewdeep learning algorithmsmedical image segmentationclinical diagnostic toolsexplainable AI models

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Area of Science:

  • Computational neuroscience and Artificial Intelligence diagnostics
  • Oncology imaging and clinical informatics research

Background:

No prior work had resolved the discrepancy between high-performing computational models and their absence in real-world clinical settings. Researchers often struggle to translate experimental diagnostic tools into standard hospital workflows. While abnormal cell growth detection remains a priority, the current landscape of automated analysis lacks standardized implementation. This uncertainty drove the need to evaluate how various automated diagnostic frameworks perform across diverse medical datasets. Prior research has shown that early detection significantly improves patient survival rates while lowering overall healthcare expenditures. Despite these benefits, the transition from academic prototypes to bedside utility remains stalled. This gap motivated a comprehensive assessment of existing literature to pinpoint why these technologies have not achieved widespread adoption. Understanding the limitations of current diagnostic models is necessary for advancing future medical imaging solutions.

Purpose Of The Study:

The aim of this study is to provide a systematic review of computational techniques used for identifying and analyzing brain tumors. Researchers sought to evaluate the current state of automated diagnostic tools in medical imaging. The project addresses the challenge of translating experimental algorithmic successes into practical, hospital-based applications. By examining existing literature, the authors intended to identify common methods, datasets, and performance metrics. They also aimed to uncover significant gaps in the current research, such as the lack of explainable models. This investigation was motivated by the need to understand why automated systems have not yet been fully adopted by clinicians. The authors provide a structured overview of the field to guide future development efforts. This work serves as a baseline for assessing the maturity of automated diagnostic technologies in oncology.

Main Methods:

The review approach followed the established Kitchenham and Charters protocol to ensure rigorous selection of relevant academic literature. Investigators searched the IEEE Xplore and ACM bibliographic databases to capture studies published between 2013 and 2024. Initial screening yielded 3,950 potential documents, which were subsequently refined using specific inclusion and exclusion criteria. This filtering process resulted in a final set of 101 papers for detailed evaluation. The team defined seven distinct research questions to categorize methods, datasets, and performance metrics. They also examined the prevalence of explainable approaches within the selected studies. This systematic design allowed for a comprehensive mapping of the current technological landscape. The methodology emphasizes transparency in how evidence was gathered and synthesized from the broader field.

Main Results:

Key findings from the literature reveal that 101 papers met the criteria for inclusion out of 3,950 initially identified sources. The analysis confirms that despite extensive research into segmentation and classification, no automated methods have achieved full clinical integration. The authors identified a significant research gap regarding weakly-supervised segmentation techniques, which remain largely unaddressed in the current body of work. Furthermore, only four articles focused on explainable approaches, indicating a major deficiency in model transparency. The review highlights that most existing studies prioritize performance metrics over the interpretability required for medical decision-making. These results demonstrate that while technical progress is evident, the field lacks the necessary focus on clinical deployment and model explainability. The data suggests an urgent need for research that addresses these specific limitations to improve diagnostic utility. The findings underscore a disconnect between academic performance and the practical requirements of oncology departments.

Conclusions:

The authors suggest that current computational diagnostic models have not yet achieved full integration into standard clinical workflows. Synthesis and implications indicate that while segmentation and classification tasks receive significant attention, practical application remains limited. The review highlights a notable scarcity of research concerning weakly-supervised segmentation techniques for brain lesions. This finding suggests that current methodologies may struggle with datasets lacking precise, pixel-level annotations. The authors emphasize that only a small fraction of studies prioritize explainable models, which are vital for medical transparency. Greater focus on interpretable decision-making processes could bridge the trust gap between clinicians and automated systems. Future investigations should prioritize these transparent frameworks to enhance diagnostic reliability in oncology. The synthesis confirms that bridging the divide between experimental success and clinical utility requires addressing these specific technical and interpretative shortcomings.

The authors report that while deep learning models effectively segment and classify lesions, no automated system has reached full clinical adoption. This discrepancy exists despite the potential for these tools to improve diagnostic speed and reduce healthcare costs compared to manual interpretation.

The researchers utilized the Kitchenham and Charters methodology to systematically filter 3,950 initial records down to 101 relevant studies. This structured approach ensured that the analysis focused on high-quality literature published between 2013 and 2024.

The authors highlight that transparency is necessary for clinicians to trust network predictions. Without explainable approaches, medical professionals cannot verify how a model reaches its conclusion, which limits the integration of these tools into high-stakes diagnostic environments.

The study identifies a lack of research into weakly-supervised segmentation, where models learn from limited or noisy labels. This data type is vital for reducing the burden of manual annotation compared to fully-supervised methods that require exhaustive expert labeling.

The review identified only four articles focusing on Explainable AI. This low number contrasts with the high volume of papers dedicated to standard segmentation and classification, indicating a significant imbalance in the current research focus.

The authors propose that future research must prioritize explainable models to improve diagnostic transparency. They argue that this shift is required to move beyond experimental prototypes and toward reliable, interpretable tools suitable for hospital environments.