Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jun 5, 2026

Microfluidic Chip for Axonal Injury Models Construction and Enabling Multi-Omics Analysis

Microfluidic Chip for Axonal Injury Models Construction and Enabling Multi-Omics Analysis

Published on: October 14, 2025

Advancing microfluidic nerve-on-a-chip systems: From physiological simulation to disease modeling.

Yanxue Wei¹, Xuwen Li¹, Chuanjun Zhang¹

¹College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, PR China; Tianjin Key Laboratory of Intelligent and Green Pharmaceuticals for Traditional Chinese Medicine, Tianjin, 301617, PR China.

Biomaterials Advances

|June 3, 2026

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Bridging Organ-on-a-Chip and Omics: A Multi-Dimensional Frontier in Biomedical Research.

Biotechnology and bioengineering·2026

Same author

Anatomical and Transcriptomic Analyses Revealed the Key Genes Associated with Tuber Expansion in <i>Cyperus esculentus</i> L.

Genes·2026

Same author

[Organ-on-a-chip and multi-omics collaborate to build a new model of systems biology].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology·2026

Same author

Suppressing the Electron-Phonon Coupling in 2D Perovskite Cs<sub>3</sub>Sb<sub>2</sub>I<sub>9</sub> for Lead-Free Indoor Photovoltaics.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025

Same author

Boosting near-infrared absorbance and exciton emission in perovskite-inspired Cs<sub>3</sub>Sb<sub>2</sub>I<sub>9</sub> through Sn doping.

Applied optics·2025

Same author

Synergistic optimization strategies for the development of multienzymatic cascade system-based electrochemical biosensors with enhanced performance.

Biosensors & bioelectronics·2025

This summary is machine-generated.

Nerve-on-a-Chip (NoC) systems utilize microfluidics to model complex neural functions and diseases. These advanced platforms offer new avenues for understanding neurological disorders and developing personalized medicine approaches.

Area of Science:

Neuroscience
Biotechnology
Microfluidics

Background:

The nervous system's complexity drives diverse neurological diseases.
Microfluidic chip technology offers precise control for neural research.

Purpose of the Study:

To review physiological models using Nerve-on-a-Chip (NoC) systems.
To summarize NoC applications in modeling neurological disorders.
To discuss future directions for NoC in personalized medicine.

Main Methods:

Development of microfluidic devices for three-dimensional (3D) cell cultures.
Integration of multiple cell types within microfluidic platforms.
Application of NoC systems for in vitro investigation of neural functions and diseases.

Keywords:

Disease modeling Microfluidic system Nerve cells Nerve-on-a-chip Nervous system Physiological Neurofunction

More Related Videos

A Microfluidics Approach for the Functional Investigation of Signaling Oscillations Governing Somitogenesis

A Microfluidics Approach for the Functional Investigation of Signaling Oscillations Governing Somitogenesis

Published on: March 19, 2021

Related Experiment Videos

Last Updated: Jun 5, 2026

Microfluidic Chip for Axonal Injury Models Construction and Enabling Multi-Omics Analysis

Microfluidic Chip for Axonal Injury Models Construction and Enabling Multi-Omics Analysis

Published on: October 14, 2025

A Microfluidics Approach for the Functional Investigation of Signaling Oscillations Governing Somitogenesis

A Microfluidics Approach for the Functional Investigation of Signaling Oscillations Governing Somitogenesis

Published on: March 19, 2021

Main Results:

NoC systems enable detailed study of neural functions and complex physiological behaviors.
Advances in modeling neurovascular, neurodegenerative, and neuroimmune disorders using NoC.
Demonstration of NoC platforms' utility in studying pathological mechanisms.

Conclusions:

NoC platforms are powerful tools for nervous system research.
NoC technology shows significant potential for personalized medicine in neurology.
Further development of NoC systems is crucial for advancing neurological disease understanding and treatment.