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Who sets the brakes on anxiety? A role for astrocytic histamine 3 receptors
Paula Gómez-Sotres1, Sara Mederos1
1Hospital del Mar Research Institute Barcelona (HMRIB), Barcelona, Spain.
Abstract:
Histamine has long been linked to anxiety, yet its effects vary across brain regions and conditions, indicating that its site of action remains unresolved. In this issue of Neuron, Li et al. 1 identify astrocytic H3 receptors in ventral CA1 as key cellular mechanisms, where histaminergic input triggers glial GABA release to suppress anxiety-like behavior.
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