Multifunctional BBR/PVA@PLGA coaxial electrospun membranes with osteogenic, angiogenic and barrier activities for
Ling Guo1, Zonghao Hu1,2, Long Yang1
1Department of Oral Implantology, School/Hospital of Stomatology, Lanzhou University, Lanzhou 730000, People's Republic of China.
Biomedical Materials (Bristol, England)
|June 3, 2026
Summary
This study introduces a novel berberine hydrochloride-loaded coaxial electrospun membrane (BBR/PVA@PLGA) for maxillofacial bone regeneration. The biomaterial effectively promotes bone healing and blood vessel formation while acting as a barrier.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Regenerative Medicine
Background:
- Maxillofacial bone defects pose clinical challenges.
- Conventional barrier membranes for guided bone regeneration (GBR) have limited efficacy due to lack of bioactivity.
Purpose of the Study:
- To develop and evaluate a novel multifunctional coaxial electrospun barrier membrane for enhanced maxillofacial bone regeneration.
Main Methods:
- Fabrication of a berberine hydrochloride (BBR)-loaded polyvinyl alcohol (PVA) core and poly (lactic-co-glycolic acid) (PLGA) shell membrane (BBR/PVA@PLGA).
- Characterization of membrane nanostructure, hydrophilicity, degradation, and mechanical properties.
- In vitro assessment of cytocompatibility, cell migration, osteogenic differentiation, and angiogenic activity.
Main Results:
- The BBR/PVA@PLGA membrane demonstrated favorable physicochemical properties and sustained drug release.
- Excellent cytocompatibility and enhanced cell migration were observed.
- Significant promotion of osteogenic differentiation, mineralization, and angiogenic activity in vitro.
- Effective physical barrier function preventing cellular infiltration.
Conclusions:
- The multifunctional BBR/PVA@PLGA coaxial electrospun membrane concurrently supports osteogenesis and angiogenesis.
- This biomaterial shows promising potential for maxillofacial bone defect regeneration.
