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Related Concept Videos

Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Sleep Apnea01:21

Sleep Apnea

Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
Alterations in Muscle Tone lll01:11

Alterations in Muscle Tone lll

Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...
Formation of Muscle Fibers from Myoblasts01:13

Formation of Muscle Fibers from Myoblasts

De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription factors...
Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective response...
Skeletal Muscle Relaxants: Adverse Effects01:21

Skeletal Muscle Relaxants: Adverse Effects

Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
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Related Experiment Video

Updated: Jun 5, 2026

Measurement of Mitochondrial Respiration in Human and Mouse Skeletal Muscle Fibers by High-Resolution Respirometry
08:12

Measurement of Mitochondrial Respiration in Human and Mouse Skeletal Muscle Fibers by High-Resolution Respirometry

Published on: October 4, 2024

Mitochondrial dysfunction in muscle cells induced by snoring vibrations.

Per Stål1, Roine El-Habta1, Yu-Cheng Qian1

  • 1Department of Medical and Translational Biology, Johan Bures väg 12, Biologihuset, Umeå universitet, 901 87 Umeå, Sweden.

Mitochondrion
|June 3, 2026
PubMed
Summary

Snoring vibrations disrupt muscle mitochondria by impairing RNA processing and protein synthesis, leading to dysfunction. This study reveals snoring as a stressor impacting mitochondrial health and muscle weakness in obstructive sleep apnea.

Keywords:
GlycolysisMitochondrial dysfunctionMuscle cellsObstructive sleep apneaOxidative phosphorylationSnoringVibrations

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Repeated Measurement of Respiratory Muscle Activity and Ventilation in Mouse Models of Neuromuscular Disease
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Repeated Measurement of Respiratory Muscle Activity and Ventilation in Mouse Models of Neuromuscular Disease

Published on: April 17, 2017

Related Experiment Videos

Last Updated: Jun 5, 2026

Measurement of Mitochondrial Respiration in Human and Mouse Skeletal Muscle Fibers by High-Resolution Respirometry
08:12

Measurement of Mitochondrial Respiration in Human and Mouse Skeletal Muscle Fibers by High-Resolution Respirometry

Published on: October 4, 2024

Repeated Measurement of Respiratory Muscle Activity and Ventilation in Mouse Models of Neuromuscular Disease
09:24

Repeated Measurement of Respiratory Muscle Activity and Ventilation in Mouse Models of Neuromuscular Disease

Published on: April 17, 2017

Area of Science:

  • Muscle physiology
  • Mitochondrial biology
  • Sleep medicine

Background:

  • Snoring vibrations are implicated in upper airway muscle dysfunction in obstructive sleep apnea (OSA).
  • Understanding the cellular mechanisms linking snoring to muscle weakness is crucial for OSA management.

Purpose of the Study:

  • To investigate the effects of snoring-induced vibrations on mitochondrial homeostasis in muscle cells.
  • To compare in vitro findings with mitochondrial alterations in upper airway muscles of snorers and OSA patients.

Main Methods:

  • In vitro vibration model using L6 muscle cells.
  • Proteomic and transcriptomic analysis of muscle cells and patient samples.
  • Mitochondrial respiration and glycolysis assays (Seahorse).

Main Results:

  • Vibration induced significant mitochondrial proteome remodeling, affecting oxidative phosphorylation and RNA processing.
  • Impaired RNA processing and protein synthesis were observed, leading to transcript-protein uncoupling.
  • Mitochondrial respiration collapsed, and glycolytic reserve was impaired, with persistent deficits in patients.

Conclusions:

  • Snoring vibrations act as a stressor disrupting mitochondrial homeostasis and leading to muscle dysfunction.
  • Impaired RNA processing, protein synthesis, and mechanotransduction contribute to muscle weakness in OSA.
  • Findings highlight a novel mechanism linking snoring to OSA-related muscle pathology.