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Photocurable robust gelatin-based hydrogel with strong tissue adhesion for wound closure
Shudan Xie1, Jiahui Li1, Ying Cao1
1Beijing Advanced Innovation Center for Materials Genome Engineering, State Key Laboratory for Advanced Metals and Materials, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, PR China.
Acta Biomaterialia
|June 3, 2026
Summary
A new photocurable bioadhesive, Diazirine-Gelatin-Methacryloyl (DGM), offers superior wound closure and healing. This advanced hydrogel adhesive demonstrates strong tissue adhesion and biocompatibility, outperforming traditional methods.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Wound Healing Research
Background:
- Traditional wound closure methods present limitations such as invasiveness and foreign body reactions.
- There is a critical need for advanced wound adhesives with high tissue adhesion and mechanical strength for improved wound management.
Purpose of the Study:
- To design and synthesize a novel photocurable bioadhesive hydrogel for enhanced wound closure and healing.
- To evaluate the tissue adhesion, mechanical properties, biocompatibility, and in vivo efficacy of the developed hydrogel adhesive.
Main Methods:
- Synthesis of diazirine-modified gelatin (DG) and its incorporation into a dual-network hydrogel with Gelatin Methacryloyl (GelMA) to form Diazirine-Gelatin-Methacryloyl (DGM).
- Characterization of DGM's tissue adhesion (burst pressure, lap shear strength) and mechanical properties.
- Assessment of DGM's biocompatibility in vitro and in vivo, including evaluation in a full-thickness skin incision model.
Main Results:
- The DGM hydrogel adhesive demonstrated significant tissue adhesion with a burst pressure of 324 mmHg and lap shear strength of 60 kPa.
- In vivo studies showed DGM provided reliable wound closure, reduced inflammation, promoted orderly collagen deposition, and facilitated high-quality tissue healing compared to sutures and commercial adhesives.
- DGM exhibited excellent biocompatibility in both in vitro and in vivo assessments.
Conclusions:
- The developed Diazirine-Gelatin-Methacryloyl (DGM) hydrogel adhesive offers a promising solution for wound management by balancing interfacial adhesion, mechanical strength, and biocompatibility.
- DGM facilitates effective wound closure and promotes superior tissue healing, presenting a versatile strategy for next-generation tissue adhesives.
