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Related Concept Videos

Cushing Syndrome I: Introduction01:26

Cushing Syndrome I: Introduction

Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...
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Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...
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Related Experiment Video

Updated: Jun 5, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

Cyclic Cushing's syndrome.

Elisabeth Nowak1

  • 1Department of Medicine IV, LMU University Hospital, LMU Munich, Munich, Germany.

Vitamins and Hormones
|June 3, 2026
PubMed
Summary
This summary is machine-generated.

Cyclic Cushing's syndrome (cCS) is a challenging endocrine disorder with fluctuating cortisol levels, leading to diagnostic delays. Recognizing these unpredictable cycles is key for accurate diagnosis and effective management of hypercortisolism.

Keywords:
Cushing syndromeCyclicDiagnostic challengesSpontaneous adrenal insufficiencyVariability

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Last Updated: Jun 5, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
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Published on: September 15, 2017

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
08:02

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Published on: April 25, 2016

Area of Science:

  • Endocrinology
  • Internal Medicine
  • Hormone Research

Background:

  • Physiological cortisol secretion follows a circadian rhythm.
  • Endogenous Cushing's syndrome involves pathological cortisol excess and dysregulation.
  • Cyclic Cushing's syndrome (cCS) is a subtype with alternating hypercortisolism and normal/low cortisol levels.

Purpose of the Study:

  • To review the epidemiology, etiology, diagnostic approach, and management of cyclic Cushing's syndrome.
  • To aid clinicians in recognizing and managing this complex, underdiagnosed disorder.
  • To highlight the diagnostic challenges posed by fluctuating cortisol levels in cCS.

Main Methods:

  • Serial hormonal profiling.
  • Clinical correlation.
  • Review of existing literature on cCS.

Main Results:

  • cCS presents with unpredictable oscillations in cortisol concentrations, complicating diagnosis.
  • Diagnostic procedures during eucortisolaemic phases can yield false-negative results.
  • Delayed diagnosis is common due to inconsistent biochemical findings and fluctuating clinical features.

Conclusions:

  • Recognition of cyclicity is essential for diagnosing cCS in patients with fluctuating Cushingoid features.
  • Accurate diagnosis requires serial testing and careful clinical correlation.
  • Management must account for temporal variability in cortisol excess, impacting diagnostic procedures and therapy timing.