The Novel HLA-C*03:03:77 Allele, Identified by Sanger Dideoxy Nucleotide Sequencing in a Chinese Individual
Yan-Fen Li1, Feng-Wei Li2, Pei-Pei Ding3
1Senior Department of Hematology, The Fifth Medical Center of PLA General Hospital, Beijing, China.
HLA
|June 3, 2026
Abstract:
The HLA-C*03:03:77 allele differs from HLA-C*03:03:01:01 by a single synonymous nucleotide change in exon 6.
Related Concept Videos
01:05Single Nucleotide Polymorphisms-SNPs
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
02:32Exon Recombination
The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes.
Exon shuffling follows “splice frame rules.” Each exon has three reading...
Exon shuffling follows “splice frame rules.” Each exon has three reading...