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Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

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Circulating Microplastics in Acute Ischemic Stroke: Feasibility, Variability, and Exploratory Comparisons with

Sophia Hohenstatt1,2, Gabriele Maliandi3, Dominik F Vollherbst4

  • 1Department of Neuroradiology, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany. sophia.hohenstatt@med.uni-heidelberg.de.

Clinical Neuroradiology
|June 3, 2026
PubMed
Summary

Microplastics (MPs) were found in 94% of participants, with higher levels observed in stroke patients compared to controls. This study shows blood MP quantification is feasible and suggests a link between MPs and ischemic stroke.

Keywords:
BloodEnvironmental PollutantsIschemic StrokeMicroplasticStroke

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Area of Science:

  • Environmental Science
  • Toxicology
  • Cardiovascular Science

Background:

  • Microplastics (MPs) are increasingly detected in human tissues.
  • Preclinical models link MPs to vascular injury, but human data on circulating MPs is limited.
  • Existing studies rely on surgical/autopsy samples, unsuitable for large-scale biomonitoring.

Purpose of the Study:

  • To quantify microplastics (MPs) in human whole blood using a contamination-controlled protocol.
  • To investigate potential differences in MP levels between ischemic stroke patients and healthy controls.
  • To explore the feasibility of blood-based MP quantification for clinical relevance.

Main Methods:

  • A prospective pilot study quantified MPs in whole blood from 35 participants (20 ischemic stroke, 15 healthy controls).
  • A plastic-free protocol and micro-Fourier transform infrared spectroscopy were employed for MP analysis.
  • Exploratory pooled comparison with external healthy control datasets was performed.

Main Results:

  • MPs were detected in 94% of participants (median 11.0 MPs/mL).
  • Numerically higher MP counts were observed in stroke patients (13.5 MPs/mL) vs. controls (7.0 MPs/mL), though not statistically significant in direct comparison.
  • Exploratory analysis showed significantly higher MP concentrations in stroke patients compared to a pooled healthy reference (p=0.0016).
  • Polyethylene, polypropylene, and polyethylene terephthalate were the most abundant polymers; smaller particles (20-100 µm) predominated.

Conclusions:

  • Blood-based MP quantification is feasible under clinical conditions.
  • Circulating MP levels may be elevated in acute ischemic stroke, warranting further investigation.
  • Larger, harmonized studies are essential to confirm findings and establish clinical relevance.