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Published on: September 29, 2011
Age-related loss of Y chromosome is associated with mortality after ST-segment elevation myocardial infarction
Nan Li1, Jiannan Li1, Yu Tan2
1Department of Cardiology, National Center for Cardiovascular Diseases, Fuwai Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.
Insights
Loss of Y chromosome (LOY) in blood cells is linked to higher mortality in male ST-elevation myocardial infarction (STEMI) patients. This finding suggests LOY may help identify high-risk individuals for better risk stratification.
Area of Science:
- Genetics
- Cardiovascular Medicine
- Aging Research
Background:
- Loss of Y chromosome (LOY) is a common age-related genetic alteration.
- LOY has been linked to cardiovascular diseases, but its specific impact on ST-segment elevation myocardial infarction (STEMI) is not well understood.
Purpose of the Study:
- To investigate the association between LOY in blood cells and all-cause mortality in male patients with STEMI.
- To determine if LOY can serve as a biomarker for risk stratification in this patient population.
Main Methods:
- A cohort of 928 males undergoing primary percutaneous coronary intervention for STEMI was studied.
- LOY levels in blood cells were quantified using droplet digital polymerase chain reaction.
- All-cause mortality was the primary outcome, with follow-up extending to 3 years.
Main Results:
- During a median follow-up of 3.99 years, 10.0% of patients died.
- Males with LOY ≥ 18% exhibited significantly increased adjusted hazard ratios for all-cause mortality at 1, 2, and 3 years post-STEMI compared to those with LOY < 18%.
- This association was particularly evident in patients without a history of myocardial infarction.
Conclusions:
- LOY levels of 18% or higher are associated with increased 1-, 2-, and 3-year mortality in male STEMI patients.
- LOY may function as a valuable biomarker for stratifying mortality risk in male STEMI patients.
- Further research may explore the clinical utility of LOY in cardiovascular risk assessment.
Background:
While loss of Y chromosome (LOY), a common somatic alteration with aging, has been associated with cardiovascular diseases, its specific impact on ST-segment elevation myocardial infarction (STEMI) remains underexplored.
Methods:
This study enrolled 928 males undergoing primary percutaneous coronary intervention for STEMI to investigate the impact of LOY in blood cells on all-cause mortality. LOY was measured in males using droplet digital polymerase chain reaction technique. The primary outcome was all-cause mortality.
Results:
During a median of 3.99-year follow-up, 93 males (10.0%) died. Of these, 39 (4.2%) died within 1 year, 56 (6.0%) within 2 years, and 67 (7.2%) within 3 years. Compared to males with LOY < 18% (the 90th percentile), those with LOY ≥ 18% had an increased mortality after multivariable adjustment including age, with adjusted hazard ratios (HRs) of 2.45 (95% confidence interval [CI]: 1.16-5.15; P = 0.018), 2.11 (95% CI: 1.11-4.01; P = 0.024), and 1.88 (95% CI: 1.02-3.45; P = 0.043) at 1-, 2-, and 3-year follow-up, respectively. Among males without prior MI, those with LOY ≥ 18% have higher mortality than those with LOY < 18% (adjusted HR 1.93; 95% CI: 1.01-3.67; P = 0.045), whereas no significant association is observed in males with prior MI.
Conclusions:
LOY ( ≥ 18%) is associated with an increased 1-, 2-, and 3-year mortality in male STEMI patients and may serve as a potential biomarker for risk stratification.
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