Related Experiment Video

Updated: Jun 5, 2026

Robust Mitochondrial Isolation from Rodent Cardiac Tissue
07:03

Robust Mitochondrial Isolation from Rodent Cardiac Tissue

Published on: August 23, 2024

Echoes in the powerhouse: mito-lncRNAs contribution to cardiac function and disease

Abdallah Iddy Chaurembo1,2,3, Na Xing4, Zi-Feng Huang1,2

  • 1Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, China.

Acta Pharmacologica Sinica
|June 3, 2026
PubMed

Insights

Mitochondrial-associated long non-coding RNAs (mito-lncRNAs) are crucial regulators of heart cell function and cardiovascular disease progression. Understanding their roles offers new diagnostic and therapeutic avenues for heart conditions.

Area of Science:

  • Cardiovascular Biology
  • Mitochondrial Biology
  • Non-coding RNA Research

Background:

  • Cardiovascular disease (CVD) is a leading global health issue, strongly linked to cardiomyocyte mitochondrial dysfunction.
  • Mitochondrial homeostasis, vital for cardiac function, involves oxidative phosphorylation, ROS balance, calcium handling, and mitophagy.
  • Mitochondrial-associated long non-coding RNAs (mito-lncRNAs) are emerging regulators of these essential mitochondrial processes.

Purpose of the Study:

  • To review and categorize mito-lncRNAs based on their origin and mitochondrial localization.
  • To summarize the mechanistic roles of mito-lncRNAs in cardiovascular physiology and disease.
  • To highlight the potential of mito-lncRNAs as biomarkers and therapeutic targets for CVDs.

Main Methods:

  • Literature review and synthesis of existing research on mito-lncRNAs.
  • Categorization of mito-lncRNAs by genomic origin and mitochondrial localization.
  • Analysis of mechanistic roles in various cardiovascular conditions, including specific transcript examples (LIPCAR, MALAT1, RMRP, H19, lncND5).

Main Results:

  • Mito-lncRNAs, both nuclear-encoded and mitochondrial-encoded, significantly influence mitochondrial gene expression, respiratory chain stability, metabolism, and stress responses.
  • These molecules play critical roles in the pathogenesis of acute myocardial infarction, heart failure, diabetic cardiomyopathy, pulmonary hypertension, and cardiac remodeling.
  • Specific mito-lncRNAs exhibit context-dependent effects crucial for cardiac health and disease.

Conclusions:

  • Mito-lncRNAs are key players in maintaining cardiac mitochondrial function and are implicated in CVD pathogenesis.
  • Further research into mito-lncRNA biology can yield novel diagnostic biomarkers and therapeutic strategies for cardiovascular diseases.
  • Challenges in delivery, mechanistic clarity, and detection need to be addressed for clinical translation of mito-lncRNA-based therapies.

Keywords:
Mito-lncRNAcardiovascular diseasesmitochondrial dysfunctionnon-coding RNA

More Related Videos

Viral Transgene Expression in Rodent Hearts and the Assessment of Cardiac Arrhythmia Risk05:15

Viral Transgene Expression in Rodent Hearts and the Assessment of Cardiac Arrhythmia Risk

Published on: July 27, 2022

Related Concept Videos

Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...