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Short-Term Alterations in Thiol-Disulfide Homeostasis Following ERCP: A Prospective Controlled Study.
Mehmet Asıl1, Yusuf Avcı2, Ali Can Erdem3
1Department of Gastroenterology, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
Digestive Diseases and Sciences
|June 3, 2026
Summary
Endoscopic retrograde cholangiopancreatography (ERCP) disrupts thiol-disulfide balance, indicating oxidative stress. This redox imbalance persists post-procedure, highlighting potential risks associated with ERCP for pancreaticobiliary disorders.
Area of Science:
- Biochemistry
- Medical Procedures
- Oxidative Stress
Background:
- Endoscopic retrograde cholangiopancreatography (ERCP) is a common procedure for pancreaticobiliary disorders.
- ERCP may induce systemic oxidative stress.
- Thiol-disulfide homeostasis is a key indicator of redox status.
Purpose of the Study:
- To investigate changes in thiol-disulfide homeostasis in patients undergoing ERCP.
- To assess the impact of ERCP on systemic redox balance.
Main Methods:
- Observational study comparing ERCP patients and controls.
- Measurement of serum native thiol, total thiol, and disulfide levels.
- Statistical analysis including ANCOVA and mixed-effects models.
Main Results:
- ERCP patients showed significantly lower native and total thiol levels and higher disulfide concentrations compared to controls.
- Age-adjusted analyses confirmed these significant differences.
- Redox imbalance persisted 24 hours post-ERCP, independent of pancreatitis or enzyme elevation.
Conclusions:
- ERCP leads to significant alterations in thiol-disulfide homeostasis, marked by reduced thiol pools.
- A persistent redox imbalance is observed post-ERCP.
- Findings suggest a link between pancreaticobiliary disease, ERCP, and oxidative stress.
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