Related Experiment Video

Updated: Jun 5, 2026

Antigen-Capture Enzyme-Linked Immunosorbent Assay for Specific Detection of Mycoplasma pneumoniae
06:04

Antigen-Capture Enzyme-Linked Immunosorbent Assay for Specific Detection of Mycoplasma pneumoniae

Published on: February 24, 2023

Movement Disorders and Cerebellar Syndromes Associated with Mycoplasma pneumoniae Infection: A Systematic Review

Ravindra Kumar Garg1, Shweta Pandey2, Amita Jain3

  • 1Department of Neurology, Era's Lucknow Medical College & Hospital, Era University, Lucknow, India.

Movement Disorders Clinical Practice
|June 4, 2026
PubMed
Abstract

Insights

Mycoplasma pneumoniae infections can cause rare neurological issues like cerebellar ataxia and opsoclonus-myoclonus-ataxia syndrome, often immune-mediated. Prompt treatment with antibiotics and immunotherapy leads to favorable outcomes in most patients.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Immunology

Background:

  • Mycoplasma pneumoniae is a known respiratory pathogen.
  • It is increasingly linked to neurological conditions beyond lung infections.

Purpose of the Study:

  • To review movement disorders and cerebellar syndromes associated with Mycoplasma pneumoniae.
  • Focus on clinical relevance, diagnosis, and management.

Main Methods:

  • Systematic review of case reports and series following PRISMA guidelines.
  • Extracted data on demographics, clinical features, diagnostics, CSF, neuroimaging, treatments, and outcomes.
  • Protocol registered with PROSPERO (CRD420251243903).

Main Results:

  • Analyzed 42 cases of Mycoplasma pneumoniae-associated movement disorders.
  • Cerebellar ataxia/cerebellitis (38.1%) and opsoclonus-myoclonus-ataxia syndrome (26.2%) were most common.
  • 83.4% achieved complete or near-complete recovery with treatment.

Conclusions:

  • Mycoplasma pneumoniae-related movement disorders are uncommon and often immune-mediated.
  • Cerebellar ataxia and opsoclonus-myoclonus-ataxia syndrome are frequent presentations.
  • Timely antibiotic and immunomodulatory therapy improves outcomes, though some deficits may remain.
Keywords:
Mycoplasma pneumoniaecerebellar ataxiacerebellitisimmune‐mediated neurological diseasemovement disordersopsoclonus–myoclonus syndrome

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