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Updated: Jun 5, 2026
06:04
Antigen-Capture Enzyme-Linked Immunosorbent Assay for Specific Detection of Mycoplasma pneumoniae
Published on: February 24, 2023
Movement Disorders and Cerebellar Syndromes Associated with Mycoplasma pneumoniae Infection: A Systematic Review
Ravindra Kumar Garg1, Shweta Pandey2, Amita Jain3
1Department of Neurology, Era's Lucknow Medical College & Hospital, Era University, Lucknow, India.
Movement Disorders Clinical Practice
|June 4, 2026
Summary
Mycoplasma pneumoniae infections can cause rare neurological issues like cerebellar ataxia and opsoclonus-myoclonus-ataxia syndrome, often immune-mediated. Prompt treatment with antibiotics and immunotherapy leads to favorable outcomes in most patients.
Area of Science:
- Neurology
- Infectious Diseases
- Immunology
Background:
- Mycoplasma pneumoniae is a known respiratory pathogen.
- It is increasingly linked to neurological conditions beyond lung infections.
Purpose of the Study:
- To review movement disorders and cerebellar syndromes associated with Mycoplasma pneumoniae.
- Focus on clinical relevance, diagnosis, and management.
Main Methods:
- Systematic review of case reports and series following PRISMA guidelines.
- Extracted data on demographics, clinical features, diagnostics, CSF, neuroimaging, treatments, and outcomes.
- Protocol registered with PROSPERO (CRD420251243903).
Main Results:
- Analyzed 42 cases of Mycoplasma pneumoniae-associated movement disorders.
- Cerebellar ataxia/cerebellitis (38.1%) and opsoclonus-myoclonus-ataxia syndrome (26.2%) were most common.
- 83.4% achieved complete or near-complete recovery with treatment.
Conclusions:
- Mycoplasma pneumoniae-related movement disorders are uncommon and often immune-mediated.
- Cerebellar ataxia and opsoclonus-myoclonus-ataxia syndrome are frequent presentations.
- Timely antibiotic and immunomodulatory therapy improves outcomes, though some deficits may remain.
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