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Updated: Jun 5, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

Mitigating Stroke Risk in Type 2 Diabetes Through Physical Activity: A Nationwide Population-Based Study in Sweden.

Anastasios Mavridis¹, Björn Eliasson^2,3, Dongni Buvarp^4,2

¹Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. anastasios.mavridis@gu.se.

Journal of Stroke

|June 4, 2026

Summary

Regular physical activity significantly reduces stroke risk in type 2 diabetes (T2DM) patients. Individuals with T2DM active at least three times weekly had stroke risk comparable to those without diabetes.

Keywords:

Diabetes mellitus Intracerebral hemorrhage Ischemic stroke Physical activity Prevention Risk factors

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Last Updated: Jun 5, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

Area of Science:

Cardiology
Endocrinology
Neurology

Background:

Type 2 diabetes (T2DM) is a significant risk factor for stroke.
Evidence linking physical activity to reduced stroke risk in T2DM is limited.

Purpose of the Study:

To investigate if physical activity mitigates the elevated stroke risk in individuals with T2DM.
To compare stroke risk between T2DM patients and matched non-diabetic individuals based on physical activity levels.

Main Methods:

A large cohort study using the Swedish National Diabetes Register (2010-2019).
1:3 matching of T2DM patients to individuals without diabetes based on age and sex.
Analysis of ischemic and hemorrhagic stroke incidence using Kaplan-Meier curves and Cox proportional hazards models.

Main Results:

The study included 369,704 individuals with T2DM and 1,109,112 controls.
Inactive T2DM individuals had a 36% higher risk of ischemic stroke (HR 1.36).
This elevated risk diminished with increased physical activity, becoming non-significant for those active ≥3 times/week (HR 1.05).
Higher physical activity attenuated the stroke risk associated with elevated glycated hemoglobin levels.

Conclusions:

Increased physical activity is associated with reduced stroke risk in individuals with T2DM.
Achieving at least three weekly activity sessions normalizes stroke risk to that of non-diabetic peers.
Physical activity promotion is crucial for integrated diabetes and stroke prevention strategies.