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Related Experiment Video

Updated: Jun 5, 2026

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro

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Published on: March 17, 2023

Muscle-Adipose Aging Dynamics and Inflammaging Patterns Across Ethnically Diverse Populations: Exploring Potential

Fei-Yuan Hsiao^1,2,3, Jamie Chi-Yun Wu¹, I-Tzu Chen¹

¹Graduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.

Journal of Cachexia, Sarcopenia and Muscle

|June 4, 2026

Summary

Muscle-adipose aging varies significantly by ethnicity, influenced by inflammation and fat metabolism. Metabolic efficiency, not just tissue size, is key for healthy aging across diverse populations.

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Last Updated: Jun 5, 2026

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro

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Published on: March 17, 2023

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Published on: June 9, 2023

Area of Science:

Gerontology
Metabolic Health
Comparative Physiology

Background:

Muscle-adipose aging involves body composition changes and chronic inflammation, with limited data across diverse ethnicities.
Understanding population-specific aging patterns is vital for targeted health interventions.

Purpose of the Study:

To characterize age- and sex-specific patterns of muscle mass, adiposity, and inflammation markers.
To compare these aging patterns across large cohorts from the UK, US, and Taiwan.
To investigate lipolysis-related biomarkers and the impact of BMI adjustment on aging assessments.

Main Methods:

Cross-cohort comparative analysis of UK Biobank, US NHANES, and Taiwan NAHSIT data.
Examination of age-related trajectories for muscle mass, adiposity, and muscle-to-fat ratio.
Assessment of inflammaging via C-reactive protein (CRP) and IGF-1; lipolysis via ketone bodies in the UK cohort.

Main Results:

Significant population-specific differences in muscle-adipose aging were observed.
Inflammaging patterns (increased CRP, decreased IGF-1) were consistent across cohorts.
BMI-adjusted muscle mass masked age-related deterioration; adiposity peaked earlier in Western populations.

Conclusions:

Muscle-adipose aging involves population-specific inflammatory and lipolytic reprogramming.
Metabolic efficiency, rather than absolute tissue quantity, is a key determinant of healthy aging.
Ethnically tailored reference standards are needed for improved risk stratification and interventions.