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Lara Pasovic1

  • 1Urologisk avdeling, Akershus universitetssykehus.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|June 4, 2026
PubMed
Summary
This summary is machine-generated.

Ketamine abuse can lead to severe urinary tract damage, including ulcerative cystitis and kidney failure. Early recognition of ketamine

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Area of Science:

  • Urology
  • Toxicology
  • Nephrology

Background:

  • Ketamine is known to cause significant toxicity to the urinary system.
  • Chronic ketamine use is associated with ulcerative cystitis, ureteric strictures, and hydronephrosis, potentially leading to renal failure.

Purpose of the Study:

  • To highlight a case of severe ketamine-induced ulcerative cystitis and renal failure.
  • To emphasize the importance of recognizing ketamine's urological toxicity amidst its growing therapeutic and recreational use.

Main Methods:

  • Presentation of a case study involving a previously healthy woman with severe urinary symptoms.
  • Diagnostic workup included imaging (ultrasound, CT), cystoscopy, and histological examination of bladder tissue.
  • Clinical management involved pain management, urinary diversion, and botulinum toxin injections.

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Main Results:

  • The patient presented with suprapubic pain, dysuria, hematuria, and urinary frequency.
  • Investigations revealed bladder wall edema, bilateral hydronephrosis/hydroureter, extensive bladder ulcerations, and reduced bladder capacity.
  • Histology confirmed denuded urothelium with necrosis and inflammation; the patient experienced recurrent acute renal failure.

Conclusions:

  • This case underscores the severe urological consequences of ketamine use, including ulcerative cystitis and renal failure.
  • Increased awareness of ketamine's potential for urinary tract toxicity is crucial for healthcare providers.