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Related Experiment Videos

Heidi Furre Østgård1, Paulina Luiza Majewska2, Kjell Arne Kvistad3

  • 1Rehabiliteringsklinikken, St. Olavs hospital, Trondheim.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|June 4, 2026
PubMed
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A ruptured brain aneurysm caused severe brain injury and akinetic mutism. Amantadine may help selected patients with non-traumatic brain injury, but more research is needed.

Area of Science:

  • Neurology
  • Neurosurgery
  • Neurorehabilitation

Background:

  • Aneurysmal subarachnoid haemorrhage (aSAH) presents significant morbidity and mortality.
  • Complications include rebleeding, hydrocephalus, infection, and secondary brain injury.
  • A ruptured anterior communicating artery aneurysm led to severe corpus callosum and cingulate gyrus injury.

Purpose of the Study:

  • To highlight diagnostic challenges in patients with minimal responsiveness.
  • To emphasize the importance of individualized rehabilitation.
  • To explore the potential role of amantadine in treating akinetic mutism post-aSAH.

Main Methods:

  • Case report of a young adult male with a ruptured anterior communicating artery aneurysm.
  • Clinical assessment and brain imaging to evaluate injury severity.

Related Experiment Videos

  • Observation of patient response to rehabilitation and pharmacological intervention (amantadine).

    • Main Results:

    • The patient developed akinetic mutism, characterized by reduced initiative and dependence.
    • Improvement was observed, potentially due to rehabilitation or spontaneous recovery.
    • The case suggests amantadine may benefit selected patients with non-traumatic brain injury.

    Conclusions:

    • Diagnostic challenges exist for patients with minimal responsiveness.
    • Sustained, individualized rehabilitation is crucial.
    • Amantadine's efficacy and safety in non-traumatic brain injury require further investigation.