Related Experiment Video
Updated: Jun 5, 2026
03:57
Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
Changes in Echocardiographic Parameters of Cardiac Function Following Parathyroidectomy: A Meta-Analysis
Arsalan Anees1, Femi E Ayeni1,2, Senarath Edirimanne1,2
1Department of Surgery, Nepean Clinical School, The University of Sydney, Sydney, New South Wales, Australia.
Echocardiography (Mount Kisco, N.Y.)
|June 4, 2026
Summary
Parathyroidectomy improves cardiac function in primary hyperparathyroidism (PHPT) patients, particularly global longitudinal strain. This suggests a sensitive marker for subtle left ventricular improvements post-surgery.
Area of Science:
- Cardiology
- Endocrinology
- Medical Research
Background:
- Primary Hyperparathyroidism (PHPT) is linked to increased cardiovascular risk.
- Elevated calcium and parathyroid hormone levels in PHPT contribute to cardiac structural changes like left ventricular hypertrophy.
- Evidence on cardiac improvement after parathyroidectomy for PHPT is inconsistent.
Purpose of the Study:
- To evaluate echocardiographic changes after parathyroidectomy in PHPT patients.
- To clarify the impact of parathyroidectomy on cardiac structure and function.
Main Methods:
- Systematic review following PRISMA guidelines.
- Searched Medline, Embase, and Cochrane databases.
- Analyzed echocardiographic parameters from 24 studies (881 patients).
Main Results:
- Left ventricular ejection fraction showed no significant change (SMD: 0.15, p = 0.40).
- Global longitudinal strain significantly improved post-parathyroidectomy (SMD: 0.60, p < 0.00001).
- Observed reduction in E/A ratio and increased left ventricular mass indicate ongoing cardiac remodeling.
Conclusions:
- Global longitudinal strain may be a sensitive marker for left ventricular function improvement after parathyroidectomy in PHPT.
- Further research is needed to assess the prognostic value of global longitudinal strain in cardiovascular disease.
