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Updated: Jun 5, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Rocaglamides from Aglaia odorata and nemoralisin-type diterpenoids from Aglaia lawii
Quan H Pham1,2, Hao C Le1,2, Binh T D Trinh1,2
1Faculty of Chemistry, VNUHCM-University of Science, Ho Chi Minh City, Vietnam.
Abstract:
Two new rocaglamides, rocaglaones A and B (1-2), along with the known compound rocaglaol (3), were isolated from the whole plant of Aglaia odorata. Furthermore, a new nemoralisin-type diterpenoid, nemoralisin P (4), and five known analogues (5-9) were obtained from the bark of A. lawii. Their structures were elucidated using spectroscopic methods (mainly 1D and 2D NMR). All the compounds were evaluated for their α-glucosidase inhibitory activity and nemoralisin P (4) exhibited the strongest activity among the tested compounds (IC50 = 373.81 ± 15.48 µM), which was comparable to that of the positive control, acarbose (IC50 = 416.92 ± 10.93 µM). Cytotoxicity testing of selected compounds against HepG2 cells revealed no detectable activity.
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