Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Varicose Veins I: Introduction01:26

Varicose Veins I: Introduction

Varicose veins, or varicosities, are abnormally dilated and twisted superficial veins caused by venous valve incompetence. This condition commonly affects the lower extremities, especially the saphenous veins, due to the higher pressure from prolonged standing and walking. However, varicosities can also occur in other areas, such as the esophagus, vulva, spermatic cords, and anorectal region.Etiology and typesPrimary varicose veins, often idiopathic, are more common in women due to inherent...
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
Esophageal Varices-I: Introduction01:24

Esophageal Varices-I: Introduction

Esophageal varices are dilated, tortuous veins which are found mainly in the submucosa of the lower esophagus but which may also appear higher up or extend into the stomach. They develop due to increased pressure in the portal venous system, often as a result of liver cirrhosis. This condition scars and damages the liver, impeding normal blood flow through the portal vein. To compensate, blood seeks alternative pathways, forming fragile new vessels (varices) in the esophagus and stomach. These...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Secondary Analysis of the CAN-Study, a Randomised Controlled Trial - Local Anaesthesia and Overall Survival.

Acta anaesthesiologica Scandinavica·2026
Same author

Vamorolone for Duchenne Muscular Dystrophy: A Cross-Trial Efficacy Comparison With Classic Corticosteroids From the FOR-DMD Trial.

Neurology·2026
Same author

The brain-lung immunotherapy prognostic (BLIP) Score: a novel robust tool for prognostication in non-small cell lung cancer patients with brain metastases.

British journal of cancer·2026
Same author

Short-Term and Late-Term Effects of Psilocybin on Symptoms in Major Depression: A Randomized Clinical Trial.

JAMA network open·2026
Same author

Complications following small-molecule inhibitors for non-small cell lung cancer.

Expert review of anticancer therapy·2026
Same author

An observational study to identify selection criteria for initiation of different first line treatment options in patients with non-small cell lung cancer.

Cancer treatment and research communications·2026

Related Experiment Video

Updated: Jun 5, 2026

Venous Thrombosis Assay in a Mouse Model of Cancer
04:40

Venous Thrombosis Assay in a Mouse Model of Cancer

Published on: January 5, 2024

Risk Factors for Developing Venous Thromboembolism in Patients With Advanced ALK-Rearranged NSCLC.

Caroline Kamali1,2, Georgios Tsakonas1,2, Rolf Lewensohn1

  • 1Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.

JTO Clinical and Research Reports
|June 4, 2026
PubMed
Summary
This summary is machine-generated.

Patients with ALK-positive NSCLC face a higher risk of venous thromboembolism (VTE). Adrenal metastases, high leukocyte count, and anemia are key risk factors for VTE in these patients.

Keywords:
Advanced diseaseAnaplastic lymphoma kinase translocationEML4-ALK fusion variantsNon–small cell lung cancerVenous thromboembolism

Related Experiment Videos

Last Updated: Jun 5, 2026

Venous Thrombosis Assay in a Mouse Model of Cancer
04:40

Venous Thrombosis Assay in a Mouse Model of Cancer

Published on: January 5, 2024

Area of Science:

  • Oncology
  • Hematology
  • Pulmonology

Background:

  • Patients with non-small cell lung cancer (NSCLC) have an elevated risk of venous thromboembolism (VTE).
  • Individuals with anaplastic lymphoma kinase (ALK) rearrangements exhibit a significantly higher VTE risk compared to those with other oncogenic drivers.
  • VTE is associated with a poorer prognosis in NSCLC patients.

Purpose of the Study:

  • To investigate the incidence of VTE in patients with advanced ALK-positive NSCLC.
  • To identify risk factors associated with VTE development in this patient population.
  • To assess the impact of VTE on the overall survival of patients with advanced ALK-positive NSCLC.

Main Methods:

  • Retrospective analysis of advanced ALK-positive NSCLC patients treated between 2009 and 2021.
  • Recording of VTE events from 90 days prior to diagnosis until death or end of follow-up.
  • Survival impact assessed using time-dependent Cox models and risk factors evaluated with Fine-Gray competing risk regression.

Main Results:

  • A total of 97 patients were analyzed, with 35 (36.1%) experiencing VTE events.
  • Pulmonary embolism was the most common VTE type (68.6%), with many occurring after 6 months of treatment.
  • VTE was associated with a 3.43-fold increased risk of death.
  • Baseline adrenal metastasis, elevated leukocyte count, and low hemoglobin were significant risk factors for VTE.
  • Higher serum albumin levels were associated with a reduced risk of VTE.

Conclusions:

  • Baseline adrenal metastases, leukocytosis, and anemia are significant risk factors for VTE in advanced ALK-positive NSCLC.
  • These findings suggest heightened clinical vigilance for VTE in patients with these specific risk factors.
  • Early identification and management of VTE risk factors may improve outcomes for ALK-positive NSCLC patients.