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Related Concept Videos

Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...

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Related Experiment Video

Updated: Jun 5, 2026

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

AI-Enabled or Digitally Augmented Adherence Systems for Chronic Care: Smart Pillboxes and Personalized Medication

Raja Waqas1, Kiranjot Kaur2,3,4, Haleema Sadia5

  • 1Regulatory Sciences and Health Safety, Arizona State University, Tempe, USA.

Cureus
|June 4, 2026
PubMed
Summary

AI and digital tools show mixed results for improving medication adherence in chronic diseases. More research is needed to confirm benefits due to inconsistent findings and study limitations.

Keywords:
artificial intelligencechronic diseasedigital healthmedication adherencepatient safetyquality improvementsmart pillbox

Related Experiment Videos

Last Updated: Jun 5, 2026

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

Area of Science:

  • Digital Health
  • Artificial Intelligence in Medicine
  • Chronic Disease Management

Background:

  • Medication adherence is crucial for managing chronic diseases.
  • Interventions using AI and digital augmentation are emerging to improve adherence.
  • Evidence on the effectiveness of these digital adherence interventions is still developing.

Purpose of the Study:

  • To systematically review AI-enabled and digitally augmented medication adherence interventions.
  • To evaluate the impact of these interventions on adherence and clinical outcomes in chronic disease populations.

Main Methods:

  • Systematic literature search across major databases (PubMed, Embase, Scopus, Cochrane Library) up to February 2026.
  • Inclusion of seven studies: randomized controlled trials and observational studies.
  • Narrative synthesis due to heterogeneity in interventions and outcome measures.

Main Results:

  • Several AI-enabled and digital interventions reported improvements in medication adherence.
  • Findings were inconsistent across studies, with one large trial showing no significant benefit.
  • Limited and variably reported evidence exists for clinical and system-level outcomes.

Conclusions:

  • Digitally supported adherence interventions show potential benefits for chronic disease management.
  • Conclusions are limited by small sample sizes, intervention heterogeneity, and moderate-to-high risk of bias in included studies.
  • Further high-quality research is required to establish the efficacy of these interventions.