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06:15
Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
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Pembrolizumab-Induced Eruptive Keratoacanthomas Managed With Intralesional Corticosteroids: A Case Report
Kevin Varghese1, Develyn Vetos1, Jason Woods1
1Dermatology, University of Kansas Medical Center, Kansas City, USA.
Cureus
|June 4, 2026
Summary
Pembrolizumab immunotherapy can cause eruptive squamous lesions. Intralesional triamcinolone effectively managed these immune-related skin events, allowing continued cancer treatment.
Area of Science:
- Dermatology
- Oncology
- Immunology
Background:
- Pembrolizumab (PD-1 inhibitor) treats various cancers but can cause immune-mediated skin reactions.
- Eruptive squamous cell carcinomas and keratoacanthomas are known side effects, potentially arising from immune activation.
- Distinguishing keratoacanthomas from well-differentiated squamous cell carcinomas requires clinicopathologic correlation.
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