Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cushing Syndrome I: Introduction01:26

Cushing Syndrome I: Introduction

Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...
Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2 (COX-2),...
Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Delivering effective non-invasive ventilation in amyotrophic lateral sclerosis using intensive remote support (DENIM): protocol for an embedded process evaluation in a hybrid type 3 implementation-effectiveness trial.

Implementation science communications·2026
Same author

Barriers to the provision of mobility assistive technology in Saudi Arabian healthcare: a mixed-methods study using the Consolidated Framework for Implementation Research.

Disability and rehabilitation. Assistive technology·2026
Same author

How physiotherapists personalize airway clearance in children with primary ciliary dyskinesia.

Physiotherapy theory and practice·2026
Same author

Update and Practical Recommendations for the Use of Medical Treatment of Cushing Syndrome.

Endocrine reviews·2026
Same author

Reducing health inequalities in the deaf community: a priority setting exercise.

BMC health services research·2025
Same author

The PRAMS (Perinatal Redesign for Accessing Mental Health Services) Study: a research protocol.

BJGP open·2025

Related Experiment Video

Updated: Jun 5, 2026

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
08:02

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Published on: April 25, 2016

Medical therapy in mild autonomous cortisol secretion.

Alan Kelsall1, Michelle Agboola1, Evie Bryden1

  • 1School of Medicine and Population Health, University of Sheffield, Sheffield S10 2RX, UK.

Journal of the Endocrine Society
|June 4, 2026
PubMed
Summary
This summary is machine-generated.

Medical therapy for mild autonomous cortisol secretion (MACS) is under-researched. Limited studies suggest potential benefits of metyrapone or mifepristone for MACS, highlighting the need for larger trials.

Keywords:
medical therapymifepristonemild autonomous cortisol secretionsystematic scoping review metyrapone

More Related Videos

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice
07:13

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice

Published on: October 24, 2018

Related Experiment Videos

Last Updated: Jun 5, 2026

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
08:02

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Published on: April 25, 2016

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice
07:13

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice

Published on: October 24, 2018

Area of Science:

  • Endocrinology
  • Pharmacology

Background:

  • Mild autonomous cortisol secretion (MACS) is increasingly prevalent with age.
  • MACS is linked to cardiometabolic issues and higher mortality.
  • Current guidelines favor conservative management or surgery; no medications are licensed for MACS.

Purpose of the Study:

  • To systematically review evidence on medical therapies for MACS.
  • To identify research gaps in MACS treatment.
  • To define outcome measures for future clinical trials.

Main Methods:

  • Comprehensive literature search of MEDLINE, EMBASE, and trial registries.
  • Screening of titles and abstracts, followed by full-text review.
  • Inclusion of studies on medical treatments for MACS.

Main Results:

  • Thirteen studies (5 full-text, 8 abstracts) met inclusion criteria.
  • Metyrapone and mifepristone were studied in 2 and 3 studies, respectively.
  • Common outcomes included blood pressure, glucose, weight, and side effects.

Conclusions:

  • Significant knowledge gaps exist regarding medical management of MACS.
  • Preliminary evidence suggests potential benefits of mifepristone or metyrapone.
  • Urgent need for large, prospective studies with defined outcome measures.