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Updated: Jun 5, 2026
08:31
A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
Published on: October 16, 2021
Contemporary Transcatheter Approaches to Mitral Regurgitation
Panagiotis Theofilis1, Panagiotis Iliakis1, Kyriakos Dimitriadis1
1Department of Cardiology, "Hippokration" General Hospital of Athens, 11527 Athens, Greece.
Reviews in Cardiovascular Medicine
|June 4, 2026
Summary
Transcatheter mitral valve repair and replacement offer new hope for patients with mitral regurgitation (MR) who are not candidates for surgery. These advanced treatments improve outcomes and reduce mortality in carefully selected individuals.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Valvular Heart Disease
Background:
- Mitral regurgitation (MR) is a common heart valve disease, particularly in heart failure patients, worsening prognosis.
- Traditional surgical repair/replacement is unsuitable for many due to age, comorbidities, or high surgical risk.
Purpose of the Study:
- To review the current landscape of transcatheter mitral valve interventions.
- To discuss the role and outcomes of various transcatheter approaches for MR management.
Main Methods:
- Review of randomized trials and registries on transcatheter mitral repair and replacement devices.
- Discussion of device-specific techniques, including mitral transcatheter edge-to-edge repair (MTEER), annuloplasty, and transcatheter mitral valve replacement (TMVR).
Main Results:
- MTEER has shown reduced hospital readmissions and improved mortality in selected secondary MR patients.
- Annuloplasty devices target functional MR, while TMVR addresses complex anatomies or MTEER ineligibility.
- Severe mitral annular calcification presents unique challenges requiring tailored strategies.
Conclusions:
- Transcatheter mitral interventions are transforming MR management for high-risk patients.
- Careful patient selection based on MR etiology, anatomy, and ventricular function is crucial for successful outcomes.
- Ongoing device development and procedural refinement continue to expand treatment options.
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