Related Experiment Video
Updated: Jun 5, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Evaluation of antimicrobial orders with expanded indication for use
Michael Carlone1, Jill Wesolowski1, Samantha Loutzenheiser1
1Cleveland Clinic Main Campus Hospital: Cleveland Clinic, Cleveland, USA.
Objective:
To evaluate the impact of requiring infectious source selection on systemic antimicrobial orders for stewardship tracking.
Design And Setting:
Multicenter, health system quality improvement project across 17 hospitals and 21 emergency departments.
Methods:
All inpatient and ED antimicrobial orders with an indication between September 1 and September 30, 2024 were analyzed. Primary outcome: Prevalence of selected infectious sources. Secondary outcomes: indication frequency, free-text use, and concordance between selected and documented sources in 500 random orders.
Results:
Among 57,118 orders, empiric indication was most common (71%). Top sources: respiratory (23%), urinary/renal (19%), skin/soft tissue (16%). Concordance was 95%. Free-text entries (2.6%) often matched existing options; dental/oral emerged as a new category.
Conclusion:
Infectious source selection was evaluated and supports future targeted stewardship interventions.
Related Concept Videos
Antimicrobial Effectiveness
Clinical Significance of Antibiotic Resistance
Automated Microbial Diagnostics
Bioequivalence of Drugs: Drugs with Multiple Indications
Antibiotic Selection
Combined Effects of Drugs: Synergism
Such synergistic combinations...
