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Related Concept Videos

Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

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Updated: Jun 5, 2026

A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease
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Published on: March 1, 2022

Inflammatory Stromal Aging in Ulcerative Colitis and Colitis-Associated Cancer.

Khalil Almotah1,2, Uyen Tran1, Haylee Gilbert1

  • 1Dept. Cardiovascular & Metabolic Sciences, Cleveland Clinic Research, Cleveland Clinic, 9500 Euclid Avenue, Cleveland OH 44195.

Biorxiv : the Preprint Server for Biology
|June 4, 2026
PubMed
Summary
This summary is machine-generated.

Colon fibroblasts in ulcerative colitis develop a pro-inflammatory state linked to senescence and epigenetic memory, driving cancer progression. This cellular memory sustains elevated CXCL8 expression, indicating a key role in inflammation-driven colon tumorigenesis.

Keywords:
CXCL8Colitis-associated cancerNF-κB signalingSenescence-associated secretory phenotype (SASP)fibroblastsiPSC reprogrammingulcerative colitis

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Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Area of Science:

  • Gastroenterology
  • Immunology
  • Oncology

Background:

  • Ulcerative colitis (UC) is a chronic inflammatory disease.
  • Inflammation drives UC progression from dysplasia to colon cancer.
  • Fibroblasts in the tumor microenvironment play a critical role.

Purpose of the Study:

  • To elucidate the mechanistic link between fibroblast inflammatory signals, microbial infiltration, and cellular memory in colitis.
  • To investigate the pro-inflammatory state of interstitial fibroblasts in UC and its role in disease progression.

Main Methods:

  • Analysis of primary colon fibroblasts from normal, colitis, and cancer samples.
  • In vitro studies and in vivo co-inoculation cancer models.
  • mRNA sequencing, NFκB signaling pathway analysis, and iPSC reprogramming.

Main Results:

  • Disease-associated fibroblasts exhibit an injury-induced senescence pathway.
  • Elevated CXCL8 expression in colitis and cancer fibroblasts is triggered by NFκB signaling.
  • Fibroblasts from UC patients retain epigenetic memory, sustaining high CXCL8 expression.

Conclusions:

  • The senescence-associated secretory phenotype of colon fibroblasts indicates inflammation-driven colon tumorigenesis.
  • Fibroblast epigenetic memory contributes to sustained inflammation and cancer progression in UC.