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Generation of Dispersed Presomitic Mesoderm Cell Cultures for Imaging of the Zebrafish Segmentation Clock in Single Cells

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Longitudinal Tracking Reveals Developmental Transitions in Zebrafish Clock Gene Expression.

Camila Morales Fénero, Raina E Sacksteder, Jacqueline M Kimmey

Biorxiv : the Preprint Server for Biology

|June 4, 2026

Summary

Zebrafish circadian clock genes per3 and per2 show distinct developmental regulation, indicating separate genetic programs assemble the system rather than a single onset.

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Last Updated: Jun 5, 2026

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Light Sheet Microscopy Imaging and Mounting Strategies for Early Zebrafish Embryos

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Published on: July 19, 2024

Area of Science:

Developmental Biology
Chronobiology
Genetics

Background:

Circadian clocks regulate daily rhythms, but their developmental assembly is unclear.
Understanding how circadian clock genes activate during development is crucial.

Purpose of the Study:

To investigate the developmental regulation of zebrafish circadian clock genes per3 and per2.
To determine if clock gene activation follows a common program or distinct pathways.

Main Methods:

Longitudinal luciferase reporters monitored per3 and per2 expression during zebrafish development.
Expression patterns were analyzed under different light-entrainment conditions.

Main Results:

Per3 and per2 exhibited distinct developmental expression patterns.
Two temporal frames (embryonic and larval) of circadian gene expression were identified.
Per3 showed early, bmal-dependent rhythmic expression, while per2 displayed light-responsive, bmal-independent transcription.

Conclusions:

The zebrafish circadian system is assembled through gene-specific regulatory programs, not a synchronized onset.
Developmental inputs contribute to clock gene activation before mature larval rhythms are established.