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Chinese expert consensus on the choice of initial cholesterol-lowering strategy
Na-Qiong Wu1, Xiao Wang1, Ping Ye2
1Cardiometabolic Center, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Frontiers in Pharmacology
|June 4, 2026
Summary
Effective cholesterol-lowering therapy, especially reducing low-density lipoprotein cholesterol (LDL-C), is key for preventing cardiovascular disease. This consensus offers optimized initial strategies for Chinese patients to improve LDL-C goal attainment and outcomes.
Area of Science:
- Cardiology
- Metabolic Medicine
- Public Health
Background:
- Cholesterol-lowering therapy, particularly reducing LDL-C, is crucial for preventing atherosclerotic cardiovascular disease.
- Despite improved treatment options, real-world LDL-C goal attainment in China remains suboptimal.
- Initial treatment strategy selection significantly impacts cholesterol management effectiveness, safety, and adherence.
Purpose of the Study:
- To systematically review and develop evidence-based recommendations for initiating cholesterol-lowering therapy in the Chinese population.
- To provide expert consensus on selecting initial cholesterol-lowering strategies tailored to individual patient characteristics.
- To enhance dyslipidemia prevention and management within China.
Main Methods:
- A comprehensive review of existing scientific evidence and clinical practices.
- Organization of domestic experts by the National Cardiovascular Disease Expert Committee Cardiovascular Metabolic Medicine Professional Committee.
- Development of a consensus report outlining optimized initial treatment regimens.
Main Results:
- Identification of critical factors influencing cholesterol-lowering therapy effectiveness, including initial strategy, safety, and adherence.
- Formulation of expert-guided recommendations for selecting initial cholesterol-lowering treatments.
- Emphasis on personalized treatment approaches for improved clinical outcomes.
Conclusions:
- Optimized initial cholesterol-lowering strategies are essential for improving LDL-C goal attainment in China.
- Tailoring treatment to individual characteristics enhances therapy effectiveness and patient adherence.
- This consensus aims to guide clinicians in selecting appropriate initial therapies for better cardiovascular disease prevention.
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