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Oxygen Saturation Target Achievement in Preterm Infants th Edition NRP Guidelines: A Multicenter Observational Study
Maria Favareto1, Susana Rodriguez, Ignacio Sosa-Boye
1Ibero American Society of Neonatology.
Objective:
To evaluate delivery room oxygen practices based on the 9th edition of Neonatal Resuscitation Program and preductal SpO2 at 5 minutes in preterm infants <32 weeks' gestation.
Study Design:
Prospective observational study in 9 centers across 6 Latin-American countries. Data included initial FiO2, changes during stabilization, and SpO2 at 5 minutes.
Results:
Among 173 infants, initial FiO2 was 0.3 in 71% (range:0.3-1.0). At 5 minutes, 18% were within target (SpO2 80-85%). SpO2 was <80% in 16%, between 86-95% in 49% of infants and >95% in 17%. FiO2 was increased in 55% and 35% of infants received ≥0.6 FiO2 by 5 minutes. Among 41 infants ≤26 weeks, initial FiO2 varied (0.3 -71%, 0.4-0.5-12%, 0.6-0.9-15% and 1.0-2%) and was titrated up in 73%.
Conclusion:
With adaptation of initial FiO2 range suggested by 9th edition NRP (0.3-1.0), two-thirds of preterm infants exceeded recommended SpO2 targets, suggesting potential hyperoxia exposure.
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