The Treatment of Perioral (Periorificial) Dermatitis With Topical Roflumilast 0.3% Cream: An Illustrative Case Study...

Periorificial dermatitis is a common inflammatory dermatosis most often presenting in adult women around the mouth with a distinctive sparing of the vermilion border. Involvement may also cluster around the eyes and nose. Steroid use is most commonly implicated in this condition. Treatments include topical and oral antibiotics, sulfur-based creams and cleansers, azelaic acid, and nonsteroidal anti-inflammatory agents. Roflumilast cream, 0.3%, was approved in 2022 for the treatment of chronic plaque psoriasis, including intertriginous areas. Here, we present the case of a 30-year-old female patient who presented with periorificial dermatitis, which cleared in 5 days with once daily roflumilast cream, 0.3%, without adverse events, tolerability concerns, or recurrence 11 months after treatment initiation.