Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Issues And Trends In Healthcare Delivery System01:29

Issues And Trends In Healthcare Delivery System

The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Current Trends in Nursing II01:30

Current Trends in Nursing II

Trends in nursing are multifactorial and associated with changes in society, within the nursing profession, and in other professions. Notably, telehealth and remote nursing contribute to successful healthcare delivery for numerous patients and help reduce stress for nurses due to nursing shortages. Nurses can reach patients, monitor their conditions, and interact with them using computers, audio, visual accessories, and telephones—for example, remote patient monitoring systems. Likewise,...
Preclinical Development: Overview01:28

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dose-, duration- and age-dependent effects of zoledronic acid on bone structure and mechanical properties in growing rice rats.

Frontiers in endocrinology·2026
Same author

Dental, Oral and Craniofacial Tissue Regeneration Consortium (DOCTRC): An infrastructure for accelerating regenerative therapies from discovery to clinical impact.

Journal of clinical and translational science·2026
Same author

Kinetics of De Novo Bone and Bone Marrow Niche Formation With Hybrid Click Cryogels.

Advanced healthcare materials·2026
Same author

Localized gene delivery and enhanced cell-cell communication via bio-orthogonal polymer coatings.

Regenerative engineering and translational medicine·2026
Same author

Human Progenitor T-Cell Differentiation Regulated by the Mechanical Resistance of Thymus-Mimetic Extracellular Matrices.

Advanced healthcare materials·2026
Same author

Systematic characterization of existing and novel inducible transgenic systems in human pluripotent stem cells after prolonged differentiation.

bioRxiv : the preprint server for biology·2025
Same journal

Stop kids' cavities without the drill.

Journal of the American Dental Association (1939)·2026
Same journal

Inherited dentin defects with comorbidities.

Journal of the American Dental Association (1939)·2026
Same journal

Functional and patient-reported outcomes of 3-dimensional-printed vs conventionally fabricated complete dentures: A randomized crossover clinical trial.

Journal of the American Dental Association (1939)·2026
Same journal

Interradicular multilocular radiolucency of the anterior mandible.

Journal of the American Dental Association (1939)·2026
Same journal

Dental manifestations of rare skeletal disorders: Diagnosis and treatment for the oral health care provider.

Journal of the American Dental Association (1939)·2026
Same journal

Beyond risk of bias: Strengthening systematic reviews in dentistry through structured trustworthiness assessment of randomized controlled trials.

Journal of the American Dental Association (1939)·2026
See all related articles

Related Experiment Video

Updated: Jun 5, 2026

Driving Simulation in the Clinic: Testing Visual Exploratory Behavior in Daily Life Activities in Patients with Visual Field Defects
11:12

Driving Simulation in the Clinic: Testing Visual Exploratory Behavior in Daily Life Activities in Patients with Visual Field Defects

Published on: September 18, 2012

Driving emerging technology to clinical impact.

W Benton Swanson1, David T Wu2, Mutsumi Yoshida3

  • 1Department of Oral Medicine, Infection and Immunity, School of Dental Medicine, Harvard University, Boston, MA.

Journal of the American Dental Association (1939)
|June 4, 2026
PubMed
Summary
This summary is machine-generated.

Translational research in dental regenerative medicine faces barriers to clinical impact. A new roadmap emphasizes early stakeholder input and patient-centered outcomes for successful technology adoption.

Keywords:
Dental regenerative medicineFDA regulatory scienceclinical evidence generationclinical translationpractice-based researchright-to-left paradigmtechnology adoptiontranslational research infrastructure

More Related Videos

The Immersive Cleveland Clinic Virtual Reality Shopping Platform for the Assessment of Instrumental Activities of Daily Living
08:36

The Immersive Cleveland Clinic Virtual Reality Shopping Platform for the Assessment of Instrumental Activities of Daily Living

Published on: July 28, 2022

Related Experiment Videos

Last Updated: Jun 5, 2026

Driving Simulation in the Clinic: Testing Visual Exploratory Behavior in Daily Life Activities in Patients with Visual Field Defects
11:12

Driving Simulation in the Clinic: Testing Visual Exploratory Behavior in Daily Life Activities in Patients with Visual Field Defects

Published on: September 18, 2012

The Immersive Cleveland Clinic Virtual Reality Shopping Platform for the Assessment of Instrumental Activities of Daily Living
08:36

The Immersive Cleveland Clinic Virtual Reality Shopping Platform for the Assessment of Instrumental Activities of Daily Living

Published on: July 28, 2022

Area of Science:

  • Dental, oral, and craniofacial regenerative medicine
  • Biomaterials and tissue engineering

Background:

  • Despite scientific advances, regenerative medicine technologies often fail to achieve significant clinical impact.
  • Limited adoption of breakthroughs in biomaterials and tissue engineering despite substantial investment.

Purpose of the Study:

  • To analyze translational bottlenecks hindering clinical impact of regenerative medicine technologies.
  • To propose a new framework for successful technology adoption in clinical practice.

Main Methods:

  • Analysis of translational bottlenecks including regulatory, clinical evidence, economic, and cultural barriers.
  • Review of successful strategies from the Translational Resource Center.
  • Proposal of a right-to-left translational paradigm.

Main Results:

  • Identified regulatory complexity, insufficient clinical evidence, and socio-economic factors as key barriers.
  • Highlighted successful strategies emphasizing milestone-driven development and early stakeholder engagement.
  • Proposed a translational paradigm prioritizing clinical adoption from project inception.

Conclusions:

  • Advocating for clinical evidence and outcomes that align with patient and provider needs is crucial.
  • A new roadmap is proposed to bridge the gap between emerging technologies and clinical impact in regenerative medicine.
  • Early clinical and stakeholder input is vital for successful technology translation.