Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
Bacterial Signaling01:30

Bacterial Signaling

Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unsupervised pretraining in biological neural networks.

Nature·2025
Same author

Epidemiology, antimicrobial resistance, and risk factors of infection among liver transplant patients: a retrospective study 2010-2023.

Microbiology spectrum·2025
Same author

Local Injection of Fluid Gelatin Under Contrast-Enhanced Ultrasound Guidance for Treating Active Bleeding From the Inferior Epigastric Artery: A Case Report.

The American journal of case reports·2025
Same author

Genetic Engineering of VHH Antibody Fragments for Efficient Site-Specific Conjugation to Polysaccharides.

Bioconjugate chemistry·2025
Same author

GCNT3-mediated glycosylation in cancer biology: Implications for tumorigenesis, metastasis, and therapeutic targeting.

International journal of biological macromolecules·2025
Same author

QRICH1 regulates ATF6 transcription to affect pathological cardiac hypertrophy progression.

Molecular medicine (Cambridge, Mass.)·2025

Related Experiment Video

Updated: Jun 5, 2026

Synthesis and Assay of Vibrio Quorum Sensing Inhibitors
03:29

Synthesis and Assay of Vibrio Quorum Sensing Inhibitors

Published on: May 31, 2024

Computational approaches for identifying quorum sensing inhibitors.

Lin Zhong1, Shwetlaxmi Patil2, B Lakshmi3

  • 1Institute of Synthetic Biology Industry, Hunan University of Arts and Science, Changde, 415000, China.

Molecular Diversity
|June 4, 2026
PubMed
Summary

New computational methods accelerate the discovery of quorum sensing inhibitors (QSIs) to combat antimicrobial resistance (AMR). These advanced drug discovery technologies offer promising anti-virulence therapies against multidrug-resistant bacteria.

Keywords:
Antimicrobial resistanceBiofilmDrug discoveryMolecular dockingQuorum sensing inhibitorsVirtual screening

More Related Videos

Quantification of Violacein in Chromobacterium violaceum and Its Inhibition by Bioactive Compounds
07:13

Quantification of Violacein in Chromobacterium violaceum and Its Inhibition by Bioactive Compounds

Published on: August 8, 2025

Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases
07:47

Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases

Published on: January 1, 2016

Related Experiment Videos

Last Updated: Jun 5, 2026

Synthesis and Assay of Vibrio Quorum Sensing Inhibitors
03:29

Synthesis and Assay of Vibrio Quorum Sensing Inhibitors

Published on: May 31, 2024

Quantification of Violacein in Chromobacterium violaceum and Its Inhibition by Bioactive Compounds
07:13

Quantification of Violacein in Chromobacterium violaceum and Its Inhibition by Bioactive Compounds

Published on: August 8, 2025

Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases
07:47

Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases

Published on: January 1, 2016

Area of Science:

  • Microbiology and Drug Discovery
  • Computational Biology and Cheminformatics

Background:

  • Quorum sensing (QS) is a microbial communication system regulating virulence and antimicrobial resistance (AMR).
  • Quorum sensing inhibitors (QSIs) offer a novel anti-virulence strategy against multidrug-resistant pathogens.

Purpose of the Study:

  • To review emerging computational and data-driven technologies for identifying and optimizing QSIs.
  • To highlight structure-guided QSI discovery against key bacterial pathogens.

Main Methods:

  • Virtual screening, molecular docking, and molecular dynamics simulations.
  • Quantitative structure-activity relationship (QSAR) modeling.
  • Machine learning and artificial intelligence in drug discovery.

Main Results:

  • Successful application of computational methods for QSI discovery against Pseudomonas aeruginosa and Chromobacterium violaceum.
  • Demonstration of AI and machine learning enhancing hit identification and lead optimization.
  • Identification of challenges in QSI development, including specificity and resistance.

Conclusions:

  • Computational and data-driven methods are revolutionizing QSI discovery for anti-virulence therapies.
  • Emerging technologies show significant potential to combat AMR.
  • Further research is needed to address translational limitations and resistance avoidance.