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Published on: January 12, 2020

Emerging landscape of oncogenic signaling pathways in cervical cancer

Ammad Ahmad Farooqi1, Rukset Attar2, Maria Luisa Gasparri3,4

  • 1Department of Molecular Oncology, Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan. Farooqiammadahmad@gmail.com.

Discover Oncology
|June 4, 2026
PubMed

Insights

This review explores signaling pathways like TGF/SMAD and Wnt/β-catenin in cervical cancer metastasis. Understanding these mechanisms and ubiquitination is key for developing targeted therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Cervical cancer metastasis research has advanced significantly.
  • Genomics, proteomics, and mouse models have improved understanding of metastasis.
  • Rodent models are crucial for studying metastasis mechanisms.

Purpose of the Study:

  • To review key signaling pathways involved in cervical cancer progression.
  • To highlight the role of ubiquitination in cervical cancer.
  • To integrate mechanistic insights with computational studies for a better understanding of cancer aggressiveness.

Main Methods:

  • Literature review focusing on signaling pathways (TGF/SMAD, Wnt/β-catenin, AKT/mTOR, Notch).
  • Examination of the role of ubiquitination in cervical cancer.
  • Integration of multi-omics and single-cell sequencing technologies.

Main Results:

  • Identified pivotal roles of TGF/SMAD, Wnt/β-catenin, AKT/mTOR, and Notch signaling in cervical cancer progression.
  • Summarized the regulatory role of ubiquitination in cervical cancer.
  • Demonstrated enhanced understanding of cervical cancer aggressiveness through integrated studies.

Conclusions:

  • Mechanistic insights into signaling pathways and ubiquitination are vital for cervical cancer research.
  • Multi-scale computational studies and advanced sequencing technologies improve understanding of disease aggressiveness.
  • Integration of multi-omics and single-cell data in clinical trials will refine decision-making for targeted therapies.

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