Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

1,3,2-Dioxaborine-based mero-polyanionic dyes: high-extinction NIR-absorbing polymethines.

RSC advances·2026
Same author

Cumulative Spectroscopic Detection for Taylor Dispersion Analysis of Nanoparticles.

Analytical chemistry·2026
Same author

Controlled Nitration of Solvent Green 5 as a Platform for Functional Perylene Derivatives.

Organic letters·2026
Same author

Poly(2-oxazoline)-Based Lipid Nanocapsules Containing Free Hydroxyl Group as Promising Alternative to Conventional PEG-Lipid Nanocapsules.

ACS omega·2026
Same author

Plasmonic behaviour of poly(2-ethyl-2-oxazoline)-coated gold nanoparticles for sensing and temperature-control applications.

Nanoscale advances·2025
Same author

Bimodal Poly(lactic-co-glycolic acid) Nanocarrier with Zinc Oxide and Iron Oxide for Fluorescence and Magnetic Resonance Imaging.

Molecules (Basel, Switzerland)·2025
Same journal

Bioorthogonal Click Chemistry Engineered Bioinks for 3D Bioprinting in Osteochondral Regeneration and Osteoarthritis Therapy: A Translational Review.

ACS applied bio materials·2026
Same journal

Green Composite of Banana Powder and Graphite-Incorporated PANI Deposited on Cotton Fabric with Enhanced Humidity Sensitivity.

ACS applied bio materials·2026
Same journal

Bioactive Peptides for Oral Diseases: Biomaterial-Assisted Therapeutics and Translational Applications.

ACS applied bio materials·2026
Same journal

Click-Chemistry-Based Antibacterial Hybrid Hydrogel with Sustained Puerarin Release for Diabetic Wound Healing.

ACS applied bio materials·2026
Same journal

Nanotechnology in Plastic and Reconstructive Surgery: Emerging Innovations in Wound Healing, Aesthetic Applications, and Skin Regeneration.

ACS applied bio materials·2026
Same journal

Therapeutic Vaccines Based on Iron-Coordinated Metal-Phenolic Networks for Eradicating Drug-Resistant Staphylococcus aureus.

ACS applied bio materials·2026
See all related articles

Related Experiment Video

Updated: Jun 6, 2026

Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies
08:54

Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies

Published on: February 17, 2023

Near-Infrared Dioxaborine-Containing Polymethines for Light-Activated Anticancer Activity.

Agnesa Syniugina1, Vladyslav Polishchuk2, Isabelle Verdu3

  • 1Taras Shevchenko National University of Kyiv, Ave. Glushkova 4-g, Kyiv 03022, Ukraine.

ACS Applied Bio Materials
|June 4, 2026
PubMed
Summary
This summary is machine-generated.

New heavy-atom-free polymethine dyes show promise as near-infrared (NIR) fluorophores and photosensitizers. These dioxaborine-containing compounds exhibit potent light-activated anticancer activity with minimal dark toxicity.

Keywords:
intracellular ROS generationnear-infrared fluorophoresphotodynamic therapyphotosensitizerspolymethine dyes

More Related Videos

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
08:03

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

In Vitro and In Vivo Evaluation of Photocontrolled Biologically Active Compounds - Potential Drug Candidates for Cancer Photopharmacology
13:17

In Vitro and In Vivo Evaluation of Photocontrolled Biologically Active Compounds - Potential Drug Candidates for Cancer Photopharmacology

Published on: September 29, 2023

Related Experiment Videos

Last Updated: Jun 6, 2026

Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies
08:54

Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies

Published on: February 17, 2023

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
08:03

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

In Vitro and In Vivo Evaluation of Photocontrolled Biologically Active Compounds - Potential Drug Candidates for Cancer Photopharmacology
13:17

In Vitro and In Vivo Evaluation of Photocontrolled Biologically Active Compounds - Potential Drug Candidates for Cancer Photopharmacology

Published on: September 29, 2023

Area of Science:

  • Organic Chemistry
  • Photochemistry
  • Biomedical Engineering

Background:

  • Polymethine dyes with dioxaborine rings are effective heavy-atom-free near-infrared (NIR) fluorophores.
  • These dyes offer tunable electronic structures, strong absorption, and high fluorescence efficiency.
  • Potential applications include theranostics and photodynamic therapy.

Purpose of the Study:

  • To investigate dioxaborine-containing polymethines as photosensitizers for light-activated cancer therapy.
  • To evaluate the cytotoxicity, cellular uptake, and reactive oxygen species (ROS) generation of these novel dyes.
  • To explore their potential as theranostic agents.

Main Methods:

  • Synthesis and characterization of three dioxaborine-containing polymethines (neutral merocyanine and anionic derivatives).
  • Assessment of photophysical properties including NIR emission and singlet oxygen generation.
  • Evaluation of in vitro cytotoxicity against F98 and B16F10 cell lines under dark and light conditions (660 nm LED).
  • Cellular uptake studies using flow cytometry and confocal fluorescence microscopy.
  • Intracellular ROS generation confirmed with H2DCFDA probe and confocal imaging.

Main Results:

  • Dyes exhibited NIR emission and singlet oxygen generation.
  • Low dark toxicity observed at concentrations up to 20 μM.
  • Significant reduction in cell viability (up to 88%) upon 660 nm LED illumination at 1 μM.
  • Stronger intracellular fluorescence and cytoplasmic localization for In33 and M25In compared to B232.
  • Confirmed intracellular ROS generation.

Conclusions:

  • Dioxaborine-containing polymethines represent a promising heavy-atom-free platform for theranostics.
  • These compounds effectively integrate NIR fluorescence with potent light-activated anticancer activity.
  • Further development could lead to novel photodynamic cancer therapies.