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High-throughput Identification of Bacteria Repellent Polymers for Medical Devices

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Published on: November 5, 2016

Stable Dual-Functional Coating on Polyurethane Surface by Grafting Antibacterial-Zwitterionic Copolymer.

Meiling Zhang¹, Huihui Yuan¹, Jiaming Huang²

¹Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, PR China.

Langmuir : the ACS Journal of Surfaces and Colloids

|June 4, 2026

Summary

A new dual-functional coating was developed for medical catheters, effectively preventing bacterial biofilm and thrombus formation. This antibacterial-zwitterionic copolymer coating enhances surface properties and shows long-lasting antifouling and antibacterial efficacy.

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Surface Functionalization of Metal-Organic Frameworks for Improved Moisture Resistance

Surface Functionalization of Metal-Organic Frameworks for Improved Moisture Resistance

Published on: September 5, 2018

Area of Science:

Biomaterials Engineering
Polymer Chemistry
Surface Science

Background:

Medical catheters are prone to bacterial biofilm adhesion and thrombus formation, complicating clinical treatments.
Antifouling and antibacterial coatings offer a viable strategy to mitigate these issues on medical devices.

Purpose of the Study:

To develop a facile and eco-friendly dual-functional coating for polyurethane (PU) medical devices.
To impart antifouling and antibacterial properties to PU surfaces for improved clinical performance.

Main Methods:

Synthesized an antibacterial-zwitterionic copolymer (PMDG) using 2-methacryloyloxyethyl phosphorylcholine (MPC), dimethyl diallyl ammonium chloride (DADMAC), and glycidyl methacrylate (GMA) via one-pot aqueous polymerization.
Grafted the PMDG copolymer onto polydopamine/polyethylenimine (PDA/PEI) pretreated PU substrates through a ring-opening reaction.
Evaluated surface hydrophilicity, protein adsorption resistance, antibacterial activity, stability, biocompatibility, and hemocompatibility of the modified PU surfaces.

Main Results:

The P/P-PMDG coating significantly increased surface hydrophilicity, reducing water contact angle from 85.95° to 18.25°.
Demonstrated excellent resistance to protein adsorption and achieved up to 99% bactericidal activity.
The coating's efficacy was maintained after 4 weeks of immersion in PBS and 3 reuse cycles, showing excellent biocompatibility and hemocompatibility.

Conclusions:

The developed dual-functional coating provides a promising strategy for surface modification of medical polymeric devices.
The antibacterial-zwitterionic copolymer coating effectively enhances biofouling resistance and antibacterial efficiency.
This approach offers a robust solution for improving the safety and performance of medical catheters.