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Related Concept Videos

Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
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From Sequencing to Treatment: Operational Challenges in Translating Precision Oncology Into Clinical Practice.

Miguel Zugman1, Paulo V Campregher1,2, Jeffrey S Ross3,4

  • 1Centro de Oncologia e Hematologia Família Dayan-Daycoval, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.

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PubMed
Summary
This summary is machine-generated.

Precision oncology uses next-generation sequencing (NGS) for personalized cancer treatment. Understanding diagnostic workflows and molecular alterations is key to translating genomic insights into improved patient outcomes.

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Area of Science:

  • Genomic Medicine
  • Cancer Biology
  • Molecular Diagnostics

Background:

  • Precision oncology matches cancer therapies to individual tumor molecular biology.
  • Next-generation sequencing (NGS) and biomarker discovery are integral to modern cancer care.
  • Comprehensive molecular testing is essential for effective precision oncology.

Purpose of the Study:

  • To highlight the importance of understanding diagnostic workflows in precision oncology.
  • To discuss how technical and preanalytic variables impact genomic testing.
  • To explain the interpretation of genomic alterations and their translation into treatment decisions.

Main Methods:

  • Review of next-generation sequencing (NGS) assay designs and their influence on detection.
  • Analysis of preanalytic variables affecting molecular testing success and accuracy.
  • Examination of interpretation strategies for diverse genomic alterations.

Main Results:

  • NGS assay design (breadth, depth, chemistry) affects detectable alterations and sensitivity.
  • Preanalytic factors like tissue quality and handling are critical for successful testing.
  • Structured reporting and multidisciplinary interpretation aid clinical decision-making.

Conclusions:

  • Coordinated integration of molecular diagnostics, clinical interpretation, and healthcare systems is vital for maximizing precision oncology's impact.
  • Understanding the entire pathway from specimen acquisition to treatment decision-making improves patient outcomes.
  • Effective translation of genomic insights requires a comprehensive approach to molecular testing and interpretation.