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Related Concept Videos

Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy01:26

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and solid...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy01:26

Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy

Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...

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Related Experiment Video

Updated: Jun 6, 2026

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
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Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice

Published on: July 12, 2018

Bowel Stimulation Before Loop Ileostomy Closure Using Probiotics: Study Protocol for a Randomized Controlled Trial at

Kyeong Eui Kim1, Sung Uk Bae1, Seong Kyu Baek1

  • 1Department of Surgery, School of Medicine, Keimyung University Dongsan Medical Center, 1035 Dalgubeol-daero, Dalseo-gu, Daegu, 42601, Republic of Korea, +82-53-258-7879, +82-53-258-4170.

JMIR Research Protocols
|June 4, 2026
PubMed
Summary

This study investigates if probiotics given before ileostomy closure can improve bowel function and reduce Low Anterior Resection Syndrome (LARS) after rectal cancer surgery. Results will show if this probiotic intervention is safe and effective for patients.

Keywords:
ileostomylow anterior resection syndromeprobioticsrectal neoplasmsrectal surgery

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Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation
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Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation

Published on: September 11, 2012

Related Experiment Videos

Last Updated: Jun 6, 2026

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
08:20

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Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation
09:44

Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation

Published on: September 11, 2012

Area of Science:

  • Gastroenterology
  • Surgical Oncology
  • Microbiome Research

Background:

  • Low Anterior Resection Syndrome (LARS) is a frequent complication following rectal cancer surgery, impacting bowel function.
  • Diverting ileostomy, used during treatment, may exacerbate gut microbiota changes and worsen bowel dysfunction post-closure.
  • Limited evidence exists on pre-closure probiotic intervention to mitigate LARS.

Purpose of the Study:

  • To assess the safety, feasibility, and efficacy of stimulating the bowel with probiotics via a diverting ileostomy prior to closure.
  • To evaluate the impact of this intervention on postoperative bowel function and LARS severity in rectal cancer patients.

Main Methods:

  • A single-center randomized controlled trial involving adult rectal cancer patients (Stage II/III) scheduled for ileostomy closure.
  • Participants receive either a probiotic (Lacidofil) or placebo (saline) through the ileostomy's distal limb for two weeks pre-closure.
  • Primary outcome is the LARS score at 3 months post-closure; secondary outcomes include complications, bowel recovery, and hospital stay.

Main Results:

  • The study is in the pre-enrollment stage, with recruitment planned from March 2026 to March 2029.
  • No participants have been recruited, and no data analysis has been performed.
  • Results are anticipated for publication in 2029.

Conclusions:

  • This trial aims to provide prospective evidence on the utility of pre-ileostomy closure probiotic stimulation.
  • The findings will clarify if this strategy can safely and effectively improve bowel function and reduce LARS in rectal cancer survivors.