Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies. Common...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Potentially Preventable Mortality After Elective Colorectal Cancer Surgery: Insights From a National Surgical Mortality Audit.

ANZ journal of surgery·2026
Same author

Changes in Surgical Admissions and Outcomes During and After the COVID-19 Pandemic: An Exploration of the Australian and New Zealand Audit of Surgical Mortality (ANZASM).

ANZ journal of surgery·2026
Same author

Open Versus Hybrid and Total Minimally Invasive Transthoracic Ivor Lewis Esophagectomy Following Neoadjuvant FLOT Chemotherapy: An Australian and New Zealand Cohort Study.

World journal of surgery·2026
Same author

Total versus subtotal gastrectomy following neoadjuvant flot chemotherapy for distal diffuse gastric adenocarcinoma: an international cohort study.

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·2026
Same author

Oncological Outcomes after Elective and Emergency Resection of Small Intestinal Neuroendocrine Tumours.

Journal of gastrointestinal cancer·2026
Same author

Bowel Ischaemia was Associated with Elevated Lactate and Pyruvate in Peritoneal fluid: A Prospective Observational Pilot Study.

Chirurgia (Bucharest, Romania : 1990)·2026
Same journal

Virtual Care of Acute Diverticulitis: A Phase I/II Randomised Clinical Feasibility Trial.

ANZ journal of surgery·2026
Same journal

Intrathyroid Parathyroid Adenoma Appearance on FCH PET/CT Imaging.

ANZ journal of surgery·2026
Same journal

The Rising Demand of Emergency General Surgery: A 15-Year Study at a Metropolitan New Zealand Hospital.

ANZ journal of surgery·2026
Same journal

Changing Aetiology of Perforated Peptic Ulcers: Rising Impact of Non-Steroidal Anti-Inflammatories in Western Australia.

ANZ journal of surgery·2026
Same journal

The Role of Non-Technical Errors in Hip Fracture Mortality: A National Retrospective Cohort Study.

ANZ journal of surgery·2026
Same journal

When Early Cholecystectomy Outpaces Capacity: Post-Decision Delay, Population Growth and Six Service Solutions From a Regional Australian Cohort Study.

ANZ journal of surgery·2026
See all related articles

Related Experiment Video

Updated: Jun 6, 2026

In Vivo Mouse Model of Spinal Implant Infection
08:03

In Vivo Mouse Model of Spinal Implant Infection

Published on: June 23, 2020

Clinically Significant Infections in Surgical Mortality.

Emily-Rose Lodge1, Helena S Kopunic1, Nathan E K Procter1

  • 1Australian Capital Territory Audit of Surgical Mortality (ACTASM), Royal Australasian College of Surgeons, Australia.

ANZ Journal of Surgery
|June 4, 2026
PubMed
Summary
This summary is machine-generated.

Clinically significant infections (CSIs) in surgical patients who died were linked to more comorbidities and longer hospital stays. These infections increased unplanned events, emphasizing the need for better prevention and management strategies.

Keywords:
clinically significant infectionshospital‐acquired infectionsinfectious organismsquality of caresurgical mortalitysurgical site infectionssurgical specialty

Related Experiment Videos

Last Updated: Jun 6, 2026

In Vivo Mouse Model of Spinal Implant Infection
08:03

In Vivo Mouse Model of Spinal Implant Infection

Published on: June 23, 2020

Area of Science:

  • Medical research
  • Surgical outcomes
  • Infection control

Background:

  • Clinically significant infections (CSIs) are a major factor in surgical mortality, leading to extended hospital stays and increased death risk.
  • Understanding the burden and contributing factors of CSIs in surgical deaths is crucial for improving patient outcomes.

Purpose of the Study:

  • To examine the prevalence of CSIs in surgical deaths within the Australian Capital Territory.
  • To identify factors associated with CSIs and explore opportunities for enhancing surgical care.

Main Methods:

  • Utilized data from the Australian Capital Territory Audit of Surgical Mortality (ACTASM) from January 1, 2015, to December 31, 2024.
  • Compared surgical mortality cases with and without CSIs to analyze differences in patient characteristics and outcomes.

Main Results:

  • Out of 1089 cases, 363 involved CSIs. Patients with CSIs had more comorbidities, longer hospital stays, and fewer procedures.
  • Infections acquired during admission (pneumonia) were more common than those acquired before admission (sepsis). General surgery had the most CSIs, while urology had the highest proportion.
  • CSIs were associated with higher rates of unplanned readmissions, critical care admissions, returns to the operating theatre, and postoperative complications.

Conclusions:

  • Surgical patients with CSIs who died presented with more comorbidities and longer hospitalizations, undergoing fewer operations compared to those without CSIs.
  • Unplanned adverse events were significantly higher in patients with CSIs, highlighting their detrimental impact on surgical patient outcomes.
  • Effective preventive strategies and prompt management of CSIs are essential for optimizing patient outcomes in surgical settings.