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Impact of Smoking Cessation Duration on Postoperative Complications in Lung Cancer Surgery
Burçin Çelik1, Caner İşevi1, Mehmet Gökhan Pirzirenli1
1Department of Thoracic Surgery, School of Medicine, Ondokuz Mayis University, Samsun, Turkey.
Introduction:
This study evaluated the effect of preoperative smoking cessation duration on postoperative complications after lung cancer surgery.
Materials And Methods:
In this single-center prospective cohort study, 156 patients undergoing surgery for non-small cell lung cancer between June 2023 and June 2025 were stratified by preoperative smoking cessation duration. The primary outcome was the development of postoperative pulmonary complications (PPCs). Logistic regression was used to identify independent risk factors.
Results:
Overall complications occurred in 62 (39.7%) patients, and PPCs occurred in 52 (33.3%). Smoking cessation longer than 8 wk preoperatively was independently associated with a lower risk of PPC compared with cessation for less than 4 wk (odds ratio: 0.42; 95% confidence interval: 0.17-0.99). Subgroup analysis of the 1-8 wk window identified 8 wk as a critical clinical inflection point for PPC with 96.55% specificity. Notably, preoperative smoking cessation duration did not significantly affect the incidence of nonrespiratory complications. Smoking burden, Charlson Comorbidity Index, and receipt of neoadjuvant therapy were additional independent risk factors for PPC.
Conclusions:
Preoperative smoking cessation of at least 8 wk significantly reduces PPCs in non-small cell lung cancer surgery, whereas its impact on nonrespiratory outcomes remains limited.
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