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Updated: Jun 6, 2026

Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats
Published on: February 10, 2020
Closing the gap: Toward functional, bioengineered esophageal grafts
Dominique D Bailey1, Jianwen Que2
1Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Columbia University Vagelos College of Physicians & Surgeons and New York-Presbyterian Morgan Stanley Children's Hospital, New York, NY 10032, USA; Columbia Center for Human Development, Columbia University Medical Center, New York, NY 10032, USA.
Abstract:
In a recent Nature Biotechnology paper, Pablo De Coppi et al. integrate tissue engineering with organ transplantation in a porcine model. They demonstrate that microinjection of autologous myogenic precursors and fibroblasts into a decellularized porcine scaffold, followed by bioreactor maturation, yields a graft that functionally integrates with the native esophagus.
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