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Practical approaches to deprescribing in general practice.

Mark A Morgan1, Hui Wen Quek2, Jenny Doust3

  • 1BPharm (Hons), GradCertAppPharmPrac,@Research Fellow, Centre for Optimisation of@Medicines, School of Health and Clinical Sciences,@The University of Western Australia, Perth, WA.

Australian Journal of General Practice
|June 4, 2026
PubMed
Summary

Deprescribing, the planned reduction of medications, helps older adults avoid adverse drug events. Integrating this practice into general practice workflows is key for improving patient care and quality of life.

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Area of Science:

  • Geriatric Medicine
  • Pharmacology
  • General Practice

Background:

  • Polypharmacy is prevalent in older adults, increasing risks of adverse drug events, hospitalizations, and reduced quality of life.
  • Deprescribing, the supervised reduction or cessation of medications, is crucial for managing inappropriate polypharmacy.
  • Implementing deprescribing into routine general practice presents significant challenges.

Purpose of the Study:

  • To outline strategies for integrating deprescribing into general practitioner (GP) workflows.
  • To leverage deprescribing guidelines, conversation frameworks, patient typologies, and multidisciplinary collaborations.
  • To facilitate the systematic adoption of deprescribing in primary care settings.

Main Methods:

  • Review of existing deprescribing guidelines and conversation frameworks.
  • Development of patient typologies to guide deprescribing discussions.
  • Emphasis on multidisciplinary collaboration for integrated care.
  • Integration into routine GP workflows, including prescription renewal and health assessments.

Main Results:

  • General practitioners (GPs) are well-positioned to lead deprescribing due to their holistic patient understanding.
  • Key opportunities for initiating deprescribing include recent clinical events, health assessments, and prescribing alerts.
  • Tailored strategies based on patient typologies enhance deprescribing discussions.

Conclusions:

  • Integrating deprescribing guidelines into practice is essential for sustainable improvements.
  • Routine consideration of deprescribing during prescription renewal and prescribing audits are effective strategies.
  • GPs can effectively lead deprescribing initiatives to enhance patient care and safety.