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sFlt-1:PlGF Testing Implementation: Introducing Practice Improvement Using Principles of Change Management.

Harrison Banner1, Michael Knauer2, Angela C Rutledge2

  • 1Department of Obstetrics and Gynaecology, Division of Maternal-Fetal Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON.

Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'Obstetrique Et Gynecologie Du Canada : JOGC
|June 4, 2026
PubMed
Summary

Implementing placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) to PlGF ratio testing aids in early preeclampsia detection. Successful integration required clinical, cost, and stakeholder engagement strategies.

Keywords:
change managementimplementation scienceplacental growth factorpreeclampsia

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Area of Science:

  • Reproductive Medicine
  • Biochemistry
  • Healthcare Management

Background:

  • Preeclampsia is a serious pregnancy complication.
  • Placental growth factor (PlGF) and the sFlt-1:PlGF ratio are established biomarkers for preeclampsia.
  • Early detection and diagnosis are crucial for managing preeclampsia.

Purpose of the Study:

  • To describe the implementation process of sFlt-1:PlGF testing for preeclampsia diagnosis.
  • To highlight the application of change management principles in clinical practice adoption.
  • To identify key factors for successful integration of novel diagnostic tests.

Main Methods:

  • Utilized change management theories and principles.
  • Focused on inter-departmental collaboration and stakeholder engagement.
  • Considered clinical utility and cost-effectiveness.

Main Results:

  • Successful implementation of sFlt-1:PlGF testing was achieved.
  • Building strong inter-departmental relationships was vital.
  • Securing stakeholder buy-in and developing a strong case were essential.

Conclusions:

  • The integration of sFlt-1:PlGF testing is feasible and beneficial for early preeclampsia detection.
  • Effective change management, including stakeholder engagement, is critical for adopting new diagnostic tools.
  • A multidisciplinary approach ensures successful clinical implementation.