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Updated: Jun 6, 2026

In vitro Assessment of Aortic Regurgitation Using Four-Dimensional Flow Magnetic Resonance Imaging
Published on: February 25, 2022
Mitral Regurgitation Assessment Using a Novel Automated Three-Dimensional Color-Flow Quantification: Comparison with
Kyu Kim1, Seon Hwa Lee1, Hyun-Jung Lee1
1Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
A novel 3D Auto CFQ tool offers a feasible and reproducible method for mitral regurgitation (MR) quantification. This advanced technique demonstrates superior agreement with cardiac magnetic resonance (CMR) compared to traditional 2D PISA methods.
Area of Science:
- Cardiology
- Medical Imaging
- Echocardiography
Background:
- Accurate mitral regurgitation (MR) quantification is challenging with conventional 2D echocardiography due to geometric assumptions.
- Novel automated 3D color flow quantification (3D Auto CFQ) aims to improve MR assessment.
Purpose of the Study:
- Evaluate the feasibility and performance of 3D Auto CFQ for MR quantification.
- Compare 3D Auto CFQ with 2D PISA and CMR for MR assessment.
Main Methods:
- Retrospective analysis of 185 patients with MR using transesophageal echocardiography (TEE).
- Quantification of MR severity and regurgitant volume (RVol) by 2D PISA and 3D Auto CFQ.
- Comparison with cardiac magnetic resonance (CMR) in a subgroup of 29 patients.
Main Results:
- 3D Auto CFQ demonstrated excellent feasibility (97.3%) and reproducibility (ICC 0.96).
- 3D Auto CFQ yielded lower RVol and fewer severe MR classifications compared to 2D PISA.
- Superior agreement with CMR was observed for 3D Auto CFQ (ICC 0.92) versus 2D PISA (ICC 0.64).
Conclusions:
- 3D Auto CFQ is a feasible and reproducible method for MR quantification.
- 3D Auto CFQ provides a more accurate MR severity classification than 2D PISA.
- 3D Auto CFQ shows higher agreement with CMR, establishing its potential as a valuable tool in clinical practice.
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