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Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation
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Notch2-expressing regulatory T cells attenuate allergic rhinitis by downregulating MHC class II expression on

Yan-Ting Zhou1, Yang Xi2, Dian Zhong1

  • 1Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, 238 Jie-Fang Road, Wuhan, Hubei 430060, PR China.

Cellular Signalling
|June 4, 2026
PubMed
Summary

Notch2-expressing regulatory T cells (Tregs) are reduced in allergic rhinitis (AR). Enhancing Notch2 in Tregs suppresses AR by improving Treg function and lowering dendritic cell (DC) MHC II expression.

Keywords:
Allergic rhinitisDendritic cellsMHC class IINotch2Regulatory T cells

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