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Updated: Jun 6, 2026
Isolation of Adipose Tissue Nuclei for Single-Cell Genomic Applications
Published on: June 12, 2020
STAU1 fine-tunes adipose thermogenesis by regulating Ucp1 mRNA stability
Shuo Jiang1, Siyuan Chen2, Mengyao Wan3
1State Key Laboratory of the Pathogenesis, Prevention, and Treatment of High Incidence Diseases in Central Asia, Xinjiang Key Laboratory of Molecular Biology of Endemic Diseases, Institute of Basic Medical Sciences, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xinjiang Medical University, Urumqi, Xinjiang 830017, China; Center of Medical Laboratory, Changzhou Third People's Hospital, Changzhou, Jiangsu, 213001, China.
None:
STAU1, an RNA-binding protein central to the STAU1-mediated mRNA decay (SMD) pathway, promotes adipogenesis. This study reveals that STAU1 protein levels positively correlate with obesity severity. Adipose specific STAU1 deficient mice on a high-fat diet showed reduced weight, enhanced thermogenesis, and improved glucose tolerance. Deleting Stau1 gene in brown adipose tissue upregulated UCP1 protein. We further identified that STAU1 binds to the 3' UTR of Ucp1 mRNA. The β3 adrenergic receptor pathway enhances SMD activity, while inhibiting the cAMP-PKA pathway downregulates STAU1. Our findings establish STAU1 as a modulatory factor that adjusts thermogenic output in response to diverse thermogenic stimuli, providing insight into post-transcriptional regulation of energy balance and potential therapeutic targets for metabolic disease.
