Related Experiment Videos

Management and long-term serum urate control in gout: a population-based primary care cohort study

Maria Antonia Pou1,2,3, Carlen Reyes3,4, Daniel Martinez-Laguna3,5

  • 1Departament de Medicina, Universitat Autònoma de Barcelona, Catalonia, Spain marianpou@gmail.com.

The British Journal of General Practice : the Journal of the Royal College of General Practitioners
|June 4, 2026
PubMed

Insights

Long-term serum urate control in gout is poor, with only 12.4% of patients achieving target levels. Optimizing urate-lowering therapy (ULT) initiation, dosage, and adherence is crucial for better gout management.

Area of Science:

  • Rheumatology
  • Primary Care Medicine
  • Epidemiology

Background:

  • Gout is a common inflammatory disease with significant cardiovascular risks.
  • Current urate-lowering therapies (ULT) are effective but gout management is often suboptimal.

Purpose of the Study:

  • To assess clinical characteristics and treatment patterns in gout patients.
  • To identify factors influencing long-term serum urate (SU) control.

Main Methods:

  • Retrospective cohort study of 94,759 patients diagnosed with gout between 2012-2023.
  • Analysis of demographic, clinical, and ULT data from a large primary care database.
  • Good SU control defined as SU <6 mg/dL for >=80% of follow-up.

Main Results:

  • Only 12.4% of patients achieved good SU control, with no improvement observed over time.
  • Common comorbidities include hypertension, dyslipidaemia, diabetes, and chronic kidney disease.
  • Factors associated with poor control included delayed ULT initiation, male sex, obesity, and comorbidities.

Conclusions:

  • Long-term SU control in gout remains a significant challenge in primary care settings.
  • Early ULT initiation, dose optimization, and improved adherence are key modifiable targets.
  • Improving gout management requires a focus on these actionable strategies.
Abstract

Keywords:
allopurinolelectronic medical recordfebuxostatgouthyperuricaemiaprimary health care

Related Concept Videos

Urinary Tract Calculi IV: Nutrition Therapy and Prevention01:27

Urinary Tract Calculi IV: Nutrition Therapy and Prevention

Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
Urinary Tract Calculi III: Medical Management01:30

Urinary Tract Calculi III: Medical Management

The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance01:25

Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance

In healthy individuals, serum creatinine levels remain stable due to a balance between its constant production—primarily from muscle metabolism—and renal excretion. Creatinine is freely filtered by the glomeruli, making it a valuable marker for estimating renal function. When the glomerular filtration rate (GFR) decreases, the kidneys can only eliminate less creatinine, causing serum levels to rise.Serum creatinine concentration is widely used to estimate creatinine clearance (Clcr), a...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations01:26

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
Hypertension IV: Drug Therapy and Lifestyle Modifications01:28

Hypertension IV: Drug Therapy and Lifestyle Modifications

Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...