Related Experiment Video
Updated: Jun 6, 2026
13:56
A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
Published on: July 18, 2013
GPR35 in host-microbe interaction: Mechanisms and translational prospects
Jian Chen1, Xiaoying Cai1, Qingyun Ma1
1State Key Laboratory of Natural Medicines, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China; Laboratory of Metabolic Regulation and Drug Target Discovery, School of Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, China.
Trends in Pharmacological Sciences
|June 4, 2026
Summary
G protein-coupled receptor 35 (GPR35) is a key target for microbiome therapeutics, influencing host health through metabolic, immune, and neural pathways. Further research into its ligands could unlock new drug discovery avenues.
Area of Science:
- Host-microbe interactions
- Pharmacology
- Drug discovery
Background:
- Host-microbe interactions are crucial for understanding disease and developing new therapeutics.
- G protein-coupled receptors (GPCRs) act as sensors at the host-microbe interface.
- G protein-coupled receptor 35 (GPR35) is an orphan receptor implicated in metabolic, immune, and neural functions.
Purpose of the Study:
- To review current knowledge on GPR35-mediated host-microbe interactions in health and disease.
- To highlight the potential of GPR35 as a target for microbiome-based therapeutics.
- To discuss challenges and propose strategies for GPR35 drug discovery.
Main Methods:
- Literature review and knowledge update on GPR35 function.
- Analysis of GPR35's role in host-microbe signaling pathways.
- Discussion of therapeutic translation strategies.
Main Results:
- GPR35 plays a significant role in host-microbe interactions across metabolic, immune, and neural systems.
- Advances in GPR35 pharmacology suggest its potential for microbiome-based therapies.
- Challenges include identifying relevant endogenous ligands and managing species selectivity and signaling bias.
Conclusions:
- GPR35 represents a promising target for developing novel microbiome-based therapeutics.
- Further investigation into GPR35's endogenous ligands is necessary for clinical translation.
- Strategies are needed to ensure balanced efficacy and safety in GPR35-targeted therapies.
More Related Videos
Related Concept Videos
01:16Transduction
Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome are...
01:29Microorganisms in Medicine and Therapeutics
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
01:28Gene Regulation in Microbial Communities: Quorum Sensing
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
01:29Translational Regulation
Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...
02:28Leaky Scanning
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA. Marilyn Kozak discovered that the sequence RCCAUGG (where R stands for...
01:25Colonisation of Pathogens
Pathogen colonization of host tissues is a critical step in the development of infectious diseases. Various pathogenic microorganisms, including bacteria, fungi, viruses, and protozoa, have evolved complex strategies to attach to, invade, and persist within host environments. These mechanisms enable pathogens to establish infections, evade immune responses, and resist antimicrobial treatments.Attachment to Host CellsIn bacteria, colonization typically begins with adherence to host epithelial...