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Updated: Jun 6, 2026

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
Published on: October 9, 2014
Emerging role of G-quadruplexes in alternative splicing regulation
Aline Peynet1, Ronan Le Sénéchal1, Marc Keruzoré1
1Inserm UMR1078, 22 avenue Camille Desmoulins, Brest 29200, France; Université de Bretagne Occidentale, Faculté de Médecine et des Sciences de la Santé, 22 avenue Camille Desmoulins, Brest 29200, France; Établissement Français du Sang (EFS) Bretagne, 46 rue Félix Le Dantec, Brest 29200, France; CHRU Brest, Hôpital Morvan, Laboratoire de Génétique Moléculaire, 5 avenue Foch, Brest 29200, France.
None:
Alternative splicing (AS) allows the production of several distinct proteins from a single protein-coding gene, thereby increasing the complexity of the proteome. In this review, we focus on the role of G-quadruplexes (G4s) in AS. G4s are noncanonical secondary structures that may form in guanine-rich loci of nucleic acids. G4s may assemble in both G-rich DNA (dG4s) and RNA (rG4s) and influence various processes, such as DNA replication, transcription, AS, or translation. We present the increasingly emerging roles of rG4s in AS regulation and discuss the potential mechanisms behind these roles. Finally, we highlight human disorders associated with dysfunctions in these processes and consider the possible use of rG4s as intervention points for these conditions, with a particular focus on cancer.
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