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Updated: Jun 6, 2026
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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Renal function and cardiovascular events in predialysis care
Beatriz Escamilla-Cabrera1,2, Cristina Ramos-de Ascanio1,2, Federico González-Rinne3
1Nephrology Department, Hospital Universitario de Canarias, La Laguna, Spain.
Scientific Reports
|June 4, 2026
Summary
Cardiovascular events (CVE) in chronic kidney disease (CKD) patients are common. In advanced CKD, age, diabetes, smoking, and prior CVE, not renal function, were the primary risk factors, suggesting a need for targeted interventions.
Area of Science:
- Nephrology
- Cardiology
- Epidemiology
Background:
- Cardiovascular events (CVE) are a leading cause of morbidity and mortality in patients with chronic kidney disease (CKD).
- The association between renal function and CVE risk in advanced CKD (predialysis) remains unclear.
- Understanding these associations is crucial for developing effective preventive strategies.
Purpose of the Study:
- To evaluate the association between renal function and CVE in a prospective cohort of predialysis patients.
- To identify key risk factors for CVE in this high-risk population.
- To inform targeted interventions for reducing cardiovascular risk in advanced CKD.
Main Methods:
- Prospective observational study of 389 predialysis patients (GFR < 30 ml/min) between 2016-2022.
- Renal function assessed by measured (mGFR) and estimated (eGFR) glomerular filtration rate using multiple equations.
- Logistic regression models adjusted for traditional and CKD-specific risk factors were used to analyze associations with CVE.
Main Results:
- Over a median follow-up of 19 months, 30% of patients experienced CVE.
- Independent risk factors for CVE included older age, diabetes, smoking, and a history of prior CVE.
- Renal function (mGFR and eGFR), proteinuria, traditional CVE risk factors, and CKD-related factors were not significantly associated with CVE risk.
Conclusions:
- In predialysis CKD patients, established risk factors like age, diabetes, smoking, and prior CVE are the primary drivers of cardiovascular events.
- Renal function and proteinuria did not emerge as significant independent predictors of CVE in this cohort.
- Current guideline-based management may be effectively mitigating the impact of renal function on CVE risk, necessitating novel, targeted strategies to further reduce cardiovascular burden.
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